Sleep and Wakefulness Research

The paper identifies global hypomethylation in T cells of narcolepsy type 1 patients, linked to solo-WCGW motifs and T cell proliferation.

This study examines the differential degeneration of wake- and sleep-modulating neurons in Alzheimer's disease, finding significant loss of orexinergic neurons and relative preservation of MCHergic neurons.

The paper shows wake EEG oscillation amplitudes and aperiodic offsets correlate with sleep slow waves, reflecting sleep pressure and brain maturation across childhood and adolescence.

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

The paper identifies a half-centre oscillator in Drosophila that generates slow-wave activity linked to sleep regulation and pressure.

The paper identifies individualized temporal patterns as the main determinant of sleep spindle timing in humans, using data from 1008 participants.

This study investigates ultradian rhythms in sleep and wakefulness in rats after sleep deprivation, finding that rebounds in wakefulness and NREM sleep depend on full ultradian cycles and are mediated by changes in ultradian phase duration and arousal probability.

This study shows that sleep deprivation after fear conditioning reduces fear memories in mice, possibly through BDNF-mediated neuroadaptations in the amygdala.

This study shows that embryonic and postnatally-derived brain macrophages have distinct roles in regulating sleep-wake cycles and synaptic balance, with postnatal repopulation failing to restore normal sleep patterns.

This study examines how spontaneous oxycodone withdrawal affects sleep, circadian rhythms, and EEG dynamics in rats over time.

This study investigates how phase-specific targeted memory reactivation during sleep affects motor memory consolidation, finding that up-state cues improve performance and alter neural activity.

The paper shows sleep selectively enhances sequence memory for real-world experiences over time, with effects growing up to one year post-encoding.

The paper quantifies age-related changes in sleep slow waves using EEG data and a computational model, finding slowed dynamics, increased variability, and reduced amplitude with age.

The paper investigates the development of delta-rhythmic activity in the medulla of sleeping infant rats and finds it coincides with cortical delta emergence, suggesting a role for medullary structures in regulating sleep.

The paper investigates whether sleep can modulate social learning-induced evaluation changes by reactivating memories during sleep, finding that cue-elicited EEG activity predicts enhanced evaluation updates.

This study investigates how Adenosine Kinase affects sleep timing and homeostatic sleep response through distinct molecular pathways in mice.

This study shows sleep loss impairs myelin function by disrupting cholesterol metabolism in oligodendrocytes, leading to conduction delays and motor deficits.

This study finds that phase-amplitude coupling between spindles and slow oscillations during NREM sleep is stable and not affected by pre-sleep learning, but correlates with memory consolidation in a specific learning paradigm.

The paper shows that synaptic strength at hippocampal pathways correlates with vigilance state durations, suggesting sleep architecture influences memory through synaptic modulation.

The paper investigates EEG correlates of parasomnia experiences and finds similarities with dream-related neural activity.

This study investigates how sleep affects cerebellar processing in adult mice by examining correlations between muscle twitches, EEG, and climbing fiber activity during different sleep stages.

This study examines how network integration and centrality in the medial temporal lobe during NREM sleep relate to emotional memory retention in older adults.

The paper identifies two substates of REM sleep in mice, showing alternating high and low activation states in the somatosensory pathway involving thalamocortical spindles.

The paper investigates the role of hypocretin neurons in stabilizing sleep by examining their interaction with noradrenergic neurons.

This study tests if memory reactivation during slow wave sleep (SWS) is more effective than during sleep stage 2 (S2), finding no significant difference in memory performance.

The paper shows that sleepiness, not total sleep amount, increases seizure risk in Drosophila models by identifying the role of sleep-promoting circuits and serotonin receptors.

This study investigates the role of NPTX2 loss of function in sleep and circadian rhythm disruption, showing that NPTX2 KO mice exhibit disrupted circadian rhythms and sleep fragmentation.

This study shows that suvorexant blocks morphine-induced changes in Hcrt neurons, microglial activation, and anticipatory behavior but preserves morphine analgesia.

This study investigates how claustrum neurons interact with the cortex during different vigilance states, finding that their activity and communication efficacy are modulated by cortical synchronization and cholinergic tone.

The paper shows that sleep-dependent synapse loss in zebrafish neurons is regulated by sleep pressure, with synapse gains during wake and losses during sleep, particularly after prolonged wakefulness.