Radiation Therapy and Dosimetry

Multiscale radiobiological assessment of laser-driven very high energy electrons versus conventional electrons

This study compares the radiobiological effects of Very High Energy Electrons (VHEE) from a laser-plasma accelerator with Conventional Intermediate Energy Electrons (CIEE) from a linear accelerator across in vitro, ex vivo, and in vivo models, finding no significant differences in toxicity.

Radiotherapy Enhancement by Gold Nanocluster-functionalized Nanoliposomes Using Polychromatic Orthovoltage X-ray Irradiation

This study evaluates gold nanocluster-functionalized nanoliposomes under orthovoltage X-ray irradiation for enhanced radiotherapy in pancreatic cancer, showing increased reactive oxygen species but challenges in formulation.

Immune stromal components impede biological effectiveness of carbon ion therapy in a preclinical model of pancreatic ductal adenocarcinoma

This study evaluates carbon ion therapy's effectiveness in pancreatic ductal adenocarcinoma, finding that immune stromal components reduce its efficacy in vivo compared to in vitro results.

Experimental investigation of oxygen diffusion in the peak and valley region of minibeam patterns during X-Ray irradiation

This study experimentally investigates oxygen depletion and diffusion in minibeam irradiation, finding higher depletion rates in valley regions and diffusion between peaks and valleys.

A simple new alternative to the linear-quadratic model (and where the LQ model comes from)

The paper introduces a new dose-survival equation to model clonogenic assay data, explains the LQ model as a Taylor expansion of this equation, and proposes a framework for classifying cell radiosensitivity.

Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo

This study evaluates oxygen-ion FLASH radiation for in vitro and in vivo pancreatic cancer treatment, showing comparable tumor cell killing to standard dose rates.

Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production.

This study investigates how modifying the microstructure of a CERN CLEAR-VHEE beam at the picosecond scale affects zebrafish embryo morphogenesis and hydrogen peroxide production.

3D printed microtissue cassettes enabling high throughput proton radiobiological assays

This paper develops 3D printed microtissue cassettes for high-throughput proton radiobiological assays, showing consistent RBE values across different assays.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Ultra-High Dose Rate Helium Ion Beams: Minimizing Brain Tissue Damage while Preserving Tumor Control

This study compares ultra-high-dose rate helium ion radiotherapy (FLASH) with standard dose rate (SDR) in mice, showing FLASH reduces brain injury and neuroinflammation while maintaining tumor control.

Interferon signaling is enhanced by ATR inhibition in glioblastoma cells irradiated with X-rays, protons or carbon ions

This study shows ATR inhibition enhances IFN signaling in glioblastoma cells after X-ray, proton, and carbon-ion irradiation, with stronger effects at higher LET.

FLASH Bragg-peak irradiation with a therapeutic carbon ion beam: first in vivo results

This study shows that FLASH irradiation with carbon ions spares normal tissue and maintains tumor control in mice, similar to conventional dose-rate treatments.

Discordance in acute gastrointestinal toxicity between synchrotron-based proton and linac-based electron ultra-high dose rate irradiation

This study compares acute gastrointestinal toxicity from synchrotron-based proton and linac-based electron ultra-high dose rate irradiation in mice, finding higher toxicity with proton FLASH compared to conventional and electron treatments.