Radiation Therapy and Dosimetry

Clonogenic survival and relative biological effectiveness of pancreatic ductal adenocarcinoma under pristine and spread-out Bragg peak irradiation with protons and carbon ions.

This study measures clonogenic survival and RBE of PDAC cells under proton and carbon ion irradiation, showing RBE increases with LETD and varies between cell lines.

Proton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunity

This study shows that FLASH proton radiotherapy enhances antitumor immunity and tumor control in triple-negative breast cancer by activating STING-IRF3 pathways and CD8+ T-cell responses.

Decreased Damage for proton FLASH vs Conventional Dose Rates in Mouse Jejunum Shown by Quantitative Assessment of γ-H2AX

This study compares DNA damage in mouse jejunum after FLASH and conventional proton irradiation, finding FLASH reduces DNA damage even in hypoxic regions, suggesting oxygen-independent sparing effects.

Laser-driven VHEE pulsed fast fractionation (PFF): second-scale inter-pulse timing can modulate normal tissue toxicity in vivo

This paper shows that varying second-scale inter-pulse intervals in pulsed fast fractionation (PFF) with VHEE radiation can differentially modulate normal tissue toxicity and cell viability in vitro and in vivo.

Antibody co-administration robustly improves proton therapy with radiosensitizing nanoparticles: a mathematical modeling study

This study uses mathematical modeling to show that co-administering antibodies with nanoparticle radiosensitizers improves proton therapy outcomes by enhancing nanoparticle distribution within tumors.

DNA double-strand break yield and radiation quality of diagnostic X-rays from 40 to 120 kV: a scale-resolved microdosimetric and track-structure study

This study quantifies how DNA double-strand break yields and radiation quality vary with tube potential in diagnostic X-rays, showing target scale affects relative biological effectiveness.

Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors

This study shows that synchrotron-based proton FLASH techniques preserve neurocognitive function in mice, with neuroprotection observed across different delivery methods and dose-rate metrics.

Nanosecond laser-driven proton FLASH spares normal tissue cells by sustaining mitochondrial homeostasis and attenuating ferroptosis

This study shows that nanosecond laser-driven proton FLASH-RT spares normal tissue by preserving mitochondrial homeostasis and reducing ferroptosis, while maintaining tumor-killing efficiency.

FLASH Radiotherapy is faster than a heartbeat: A compartmental model to illustrate the interplay between tissue oxygen perfusion and ultra-high dose rate effects.

The paper develops a compartmental model to simulate oxygen perfusion and its interaction with ultra-high dose rate radiation in FLASH Radiotherapy, showing a sigmoidal dose-rate-response curve for lipid peroxidation.

Long-term Musculoskeletal and Marrow Sparing with Proton FLASH in Juvenile Mice: Implications for Pediatric Osteosarcoma

This study shows proton FLASH radiotherapy reduces long-term musculoskeletal and marrow toxicities in juvenile mice, suggesting its potential for pediatric osteosarcoma treatment.

In Silico Neutron Relative Biological Effectiveness Estimations For Pre-DNA Repair And Post-DNA Repair Endpoints

This study uses Monte Carlo simulations to estimate neutron RBE for misrepairs, finding higher peak RBE values and improved matching with Euclidean distance-based damage clusters.

FLASH or flare: variable intestinal toxicity results in a mouse model following proton pencil beam scanning irradiation on a clinical superconducting synchrocyclotron

This study evaluates FLASH proton therapy in mice, finding improved survival with FLASH but inconsistent results across irradiation rounds.

Investigating Rat-Brain Normal Tissue and Tumor FLASH Effects with a Novel Very High Energy Electron Beam

This study investigates FLASH radiation effects on rat brain tissue and tumors using a novel high-energy electron beam, finding differential immune responses and microglial changes.

Nanoparticle Metal Mass Uptake Governs Radiosensitizing Efficacy Across 2D, 3D, and In Vivo Models

This study develops a 3D spheroid model of head and neck cancer to evaluate nanoparticle radiosensitization across 2D, 3D, and in vivo settings, finding consistent effects when nanoparticle mass uptake is matched.

Monte Carlo track-structure simulation of the impact of Ultra-Hight Dose Rate and oxygen concentration on the Fenton reaction.

This study simulates the impact of ultra-high dose rate and oxygen concentration on the Fenton reaction using radiolysis of Fricke solution, showing reduced Fenton reaction yields under UHDR at low oxygen levels.

High LET Particle Therapy Targets Tumor Microtube Networks in Glioblastoma

This study investigates how high LET particle therapy affects tumor microtube networks in glioblastoma, finding that higher LET reduces TM formation and improves cell survival.

The fractionation dependence of tumor control in proton therapy for early-stage non-small cell lung cancer

This study evaluates how proton therapy's tumor control effectiveness varies with fractionation schedules in early-stage NSCLC, finding higher RBE for short-term treatments.

In vitro FLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system

This study investigates FLASH irradiation effects on lung cancer and healthy fibroblast cells using a clinical proton therapy setup, finding no significant survival differences but altered cell cycle dynamics.