Bone Metabolism and Diseases

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

This study shows LGR6 is essential for osteoblast proliferation, differentiation, and peak bone mass, with distinct signaling roles for its ligands RSPO2 and MaR1.

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.

This study identifies three human osteoblast subtypes using scRNA-seq, revealing a novel subtype with unique gene expression and functional roles in bone and hematopoiesis.

This study shows Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells toward adipogenesis through C3 and Wnt/β-catenin signaling inhibition.

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

This study identifies differentially methylated loci in blood samples of Paget's disease of bone patients, showing their potential as diagnostic markers.

This study identifies heterogeneous progenitor cell populations in murine periosteum and their roles in fracture healing.

The paper investigates the methylation status of NFATC1 and C-FOS genes in pre- and post-menopausal women and finds a significant association between NFATC1 unmethylation and post-menopausal status.

This paper outlines a protocol for a systematic review examining the role of epigenetic and transcriptional regulators in osteoclastogenesis and their association with bone disorders.

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

This study identifies OGRU, a lncRNA that alleviates unloading-induced bone loss by regulating the miR-320-3p/Hoxa10 axis in osteoblasts.

This study shows that RXR agonist SR11237 disrupts skeletal development in rats and mice by causing growth plate dysmorphia and impaired long bone growth.

The paper identifies CYLD as a mechanosensitive deubiquitinase that represses TGFβ signaling in osteocytes through PGE2 and EP2, facilitating load-induced bone formation.

This study investigates Satb2's role in pre-osteoblast proliferation and nuclear integrity, finding it regulates cell cycle progression and DNA replication, with potential implications for skeletal defects and cancer.

This study shows that loss of FGFR1 and FGFR2 in mature osteoblasts/osteocytes leads to osteocyte death and high bone mass with impaired biomechanical properties in mice.

This study identifies integrin alpha11 as the receptor for Osteolectin, showing its role in osteogenic differentiation and bone mass maintenance through Wnt pathway activation.

This paper proposes a minimal model of bone remodeling that shows efficient BMU operation emerges from simple cell-level decisions and interactions.