Bone Metabolism and Diseases

CORONAVIRUS INFECTION ACCELERATES EXPERIMENTAL OSTEOPOROSIS THROUGH THE ACTIVATION OF OSTEOCLASTS

This study shows that coronavirus infection accelerates bone loss in mice with osteoporosis by increasing osteoclast activity and inflammation.

Dysregulated mechanoregulation of load-induced bone adaptation in prematurely aged mice: insights from a micro-multiphysics agent-based model

This study uses an agent-based model to show that aging disrupts mechanoregulation of bone adaptation in mice, leading to altered bone formation and resorption dynamics.

Subchondral bone remodeling in knee osteoarthritis is coupled to lipid mobilization from bone marrow adipocytes

This study investigates the link between lipid mobilization from bone marrow adipocytes and bone formation in knee osteoarthritis, finding that lipolysis is associated with osteogenic activity and can be pharmacologically modulated.

Impaired glycolysis in bone underlies age-related bone loss in mice

This study shows that impaired glycolysis in bone tissue of aged mice leads to reduced bone formation, and that enhancing glycolysis can improve bone mass.

The CREB-regulated co-activators 2/3, have a role, in vivo, in osteoblastic gene expression.

This study investigates the in vivo role of CRTC2/3 in osteoblasts by analyzing bone phenotype and gene expression changes in conditional knockout mice.

Glucocorticoid signalling exerts distinct lineage-permissive and dose-dependent disruptive actions during human osteoblast differentiation

This study investigates how glucocorticoid signaling affects human osteoblast differentiation at different doses and contexts, revealing distinct mechanisms for lineage-permissive and disruptive effects.

Dermal bone grows by cellular invasion and intercalary biomineralization

The paper reveals that dermal bone growth involves cellular invasion and intercalary biomineralization, challenging the traditional model of matrix apposition by superficial osteoblasts.

Dermal bone remodelling by invasive osteoblasts evolved in stem gnathostomes

The paper identifies a common lineage origin of endothelial cells and osteoblasts and reveals de novo vasculogenesis as a key mechanism in dermal bone remodeling in vertebrates.

Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival

This study shows FGFR1 signaling is essential for osteocyte survival and bone homeostasis by regulating extracellular matrix organization and dendrite formation in maturing osteoblasts.

An RBP-J-heparan sulfate-dependent gatekeeper directs macrophage fate between inflammatory regulation and osteoclastogenesis

This study identifies an RBP-J-HS-dependent network that regulates macrophage fate between inflammation and osteoclastogenesis in response to TNF.

Human Osteocytes Express MHC Class II and Act as Non-classical Antigen-Presenting Cells During Bacterial Infection

This study shows human osteocytes express MHC Class II and present antigens during bacterial infection, suggesting a new role in immune surveillance.

γLinolenic Acid Induces a Vitamin D Receptor-Independent Mineralization Program by Activating CaMKII--SMAD2/3 Pathway in Calvarial Osteoblasts

This study identifies a VDR-independent mineralization pathway in osteoblasts induced by γ-linolenic acid through the CaMKII-SMAD2/3 pathway, offering a metabolic strategy to restore bone formation under vitamin D deficiency.

The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing

This study identifies a cortical niche-specific macrophage subset that drives early osteoclastogenesis in bone healing through spatial immune-stromal interactions in young mice.

Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging

This study investigates how osteocyte state transitions affect bone remodeling during early skeletal aging, finding age-dependent changes in osteocyte subpopulations and their impact on bone mass.

ZNF687 couples bone marrow myeloid progenitor dynamics toosteoclastogenesis in severe Paget's disease of bone

This study shows ZNF687 regulates bone marrow myeloid progenitor dynamics and osteoclastogenesis, linking its loss to reduced osteoclast differentiation and increased trabecular bone mass in a mouse model.

Asarinin Inhibits RANKL-Induced Osteoclast Differentiation by Targeting the p38/ERK-c-Fos-NFATc1 Axis

This study shows asarinin inhibits osteoclast differentiation by blocking the p38/ERK-c-Fos-NFATc1 pathway in RANKL-stimulated cells.

IKKβ as a putative non-covalent and quinone-mediated covalent target of 4-methylcatechol in RANKL/NF-κB signaling: a combined computational and experimental analysis

This study investigates how 4-methylcatechol affects RANKL-induced osteoclastogenesis by targeting IKKβ through non-covalent and covalent mechanisms.

Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis

This study identifies SLC3A1-mediated cystine transport as a key regulator of osteogenic fate commitment and shows cystine supplementation promotes bone regeneration and mitigates osteoporosis.

The multifaceted role of acetamide derivative of Chalcone: Anti-inflammatory Action and Impact on Osteoclastogenesis, insights on NF-kB and MAPK pathways.

This study demonstrates that chalcone derivative 7a has anti-inflammatory and anti-osteoclastogenic effects by inhibiting NF-κB and MAPK pathways.

Vitamin D mitigates Inflammatory Bone Loss in Postmenopausal Osteoporosis via modulating the Gut-Immune-Bone axis

This study shows vitamin D prevents bone loss in postmenopausal osteoporosis by modulating the gut-immune-bone axis, resolving its paradoxical effects on osteoclasts.

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

The paper identifies key cell types and genes involved in skeletal disease using single-cell analysis and validates their roles in mouse models.

Peri-Locus Coeruleus Controls Endothelial Cell Heterogeneity in Enriched Environments via Region-Specific Norepinephrine Signaling

This study shows that peri-LC neurons regulate bone endothelial heterogeneity and density through norepinephrine signaling in enriched environments.

Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Bone Microarchitecture

This paper deletes Dock7 exons 3-4 in mice, resulting in reduced trabecular bone volume and altered osteoblast function.

Piezo1 transduces mechanical signals to inhibit osteoclast fusion and coordinate bone homeostasis

This study shows that Piezo1 transduces mechanical signals to inhibit osteoclast fusion and maintain bone homeostasis by activating a signaling pathway that suppresses osteoclast differentiation.

Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity

The paper identifies methyl carnosate as a potent inhibitor of RANKL-induced osteoclastogenesis with an IC50 of 1.2 M, showing greater efficacy than carnosic acid.

Muscle-to-Bone CX3CL1 Signaling Promotes Skeletal Repair Through CX3CR1+ Osteoprogenitors

This study identifies a muscle-to-bone signaling pathway where CX3CL1 from muscle endothelial cells promotes bone repair via CX3CR1-expressing osteoprogenitors.

Intermittent parathyroid hormone employs autonomous and non-autonomous mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells

This study shows intermittent parathyroid hormone drives osteogenesis from Ebf3-expressing progenitors via both intrinsic and extrinsic mechanisms in mice and humans.

A bone fragment-based protocol for molecular analysis of osteocyte-associated transcripts in human bone specimens

This paper describes a protocol to isolate osteocyte-associated transcripts from human bone specimens by removing non-osteocytic cells through mechanical and enzymatic steps.

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse Model

This study identifies increased osteoclast activity as a key contributor to bone resorption and osteopenia in a Rett syndrome mouse model, showing an age-dependent shift in bone remodeling.

Endogenous retrotransposon activity supports osteocyte function and links antiretroviral therapy to bone loss

The paper shows that endogenous retrotransposon activity is linked to osteocyte function and bone health, and that antiretroviral drugs may impair this activity, contributing to bone loss.