Bone Metabolism and Diseases

Fibroblast Growth Factor Receptor Signaling in Maturing Osteoblasts Controls Cell-Matrix Interactions Critical for Osteocyte Survival

This study shows FGFR1 signaling is essential for osteocyte survival and bone homeostasis by regulating extracellular matrix organization and dendrite formation in maturing osteoblasts.

The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing

This study identifies a cortical niche-specific macrophage subset that drives early osteoclastogenesis in bone healing through spatial immune-stromal interactions in young mice.

Asarinin Inhibits RANKL-Induced Osteoclast Differentiation by Targeting the p38/ERK-c-Fos-NFATc1 Axis

This study shows asarinin inhibits osteoclast differentiation by blocking the p38/ERK-c-Fos-NFATc1 pathway in RANKL-stimulated cells.

The multifaceted role of acetamide derivative of Chalcone: Anti-inflammatory Action and Impact on Osteoclastogenesis, insights on NF-kB and MAPK pathways.

This study demonstrates that chalcone derivative 7a has anti-inflammatory and anti-osteoclastogenic effects by inhibiting NF-κB and MAPK pathways.

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

The paper identifies key cell types and genes involved in skeletal disease using single-cell analysis and validates their roles in mouse models.

Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity

The paper identifies methyl carnosate as a potent inhibitor of RANKL-induced osteoclastogenesis with an IC50 of 1.2 M, showing greater efficacy than carnosic acid.

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse Model

This study identifies increased osteoclast activity as a key contributor to bone resorption and osteopenia in a Rett syndrome mouse model, showing an age-dependent shift in bone remodeling.

Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice

This study identifies GAS6 as a vitamin K-dependent osteoblast-secreted protein that regulates osteoclast maturation and bone mass in male mice.

Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology

The paper uses a CRISPRi screen to identify Clip2 as a regulator of osteocyte maturation and morphology by analyzing CD61 expression and dendrite formation.

8-Epixanthatin Suppresses RANKL-Induced Osteoclast Differentiation via Inhibition of NF-κB and MAPK Signaling

This study shows 8-Epixanthatin inhibits RANKL-induced osteoclast differentiation by blocking NF-κB and MAPK signaling without significant cytotoxicity.

Alzheimer's disease risk factor APOE4 exerts dimorphic effects on female bone

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

Deoxycholic acid (DCA) alleviates LPS-induced Inflammatory Bone Loss via modulating the Gut-Bone homeostasis

This study shows that deoxycholic acid reduces LPS-induced inflammatory bone loss by improving gut microbiota balance and bone cell function.

Potential Mechanisms Underlying Kaempferol-Promoted Osteoblast Proliferation and Osteogenic Differentiation: A Network Pharmacology and Experimental Validation Study

This study identifies kaempferol's mechanisms in promoting osteoblast proliferation and osteogenic differentiation via the PI3K/AKT pathway using network pharmacology and experimental validation.

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.

This study shows that collectin-11 regulates osteoclastogenesis and bone maintenance through complement-dependent mechanisms, with combined deficiencies causing bone loss and spinal curvature in mice.

IGF-1 from bone marrow Adipoq-lineage cells stimulates endocortical bone formation in mature female mice

The paper identifies Adipoq+ stromal cells in bone marrow as a source of IGF-1 that promotes endocortical bone formation in mature female mice without affecting trabecular bone or hematopoiesis.

The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes

This study shows that PER1 inhibits osteoclastogenesis by upregulating inflammatory genes, linking circadian rhythms to bone remodeling and suggesting therapeutic targets for inflammatory bone diseases.

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

This study deletes Scarb1 in osteoblast progenitors and myeloid cells and finds no effect on bone mass.

Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective

This study investigates dexamethasone-induced bone toxicity in developing bones using single-cell transcriptomics in mice, revealing reduced osteoblast and chondrocyte populations and disrupted B cell development.

ARHGAP10 is a novel microtubule-associated protein that regulates the resorption activity of osteoclasts

This study identifies ARHGAP10 as a microtubule-associated protein critical for osteoclast function, showing it regulates actin ring dynamics and resorption activity through its interaction with microtubules and RHO-GTPases.

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.

Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis

This study shows that senescent bone marrow adipocytes secrete SAP/PTX2, which promotes skeletal amyloidosis and bone loss in aging mice.

Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors

This study shows that chronic alcohol consumption increases the differentiation of hematopoietic stem and progenitor cells into osteoclast precursors, contributing to reduced bone density.

Sexual dimorphism of MASLD-driven bone loss

This study investigates sex differences in bone loss associated with MASLD using DIAMOND mice, identifying potential liver-secreted factors involved in bone resorption.

The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.

A Novel Optimized Silver Nitrate Staining Method for Visualizing the Osteocyte Lacuno-Canalicular System

This paper introduces an optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system, showing improved staining consistency and LCS detection across species.

Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis

This paper shows cathepsin K inhibitors enhance osteoclast-osteoblast communication and promote osteogenesis, suggesting their unique role in balancing bone resorption and formation.

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts

The paper uses high-content imaging to identify anti-resorptive GPCRs in human osteoclasts, finding four receptors that reduce osteoclast activity.

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.