Neuroscience and Neural Engineering

A scalable mesh microelectrode array platform for longitudinal electrophysiology in neural spheroids

This paper introduces a mesh microelectrode array platform for longitudinal electrophysiology in neural spheroids, enabling recordings and pharmacological modulation of electrical activity.

Phasic Neural Stimulation via Frequency-Modulated Kilohertz Signals: An Alternative to Amplitude Modulation

This paper introduces and validates frequency-modulated kilohertz (FM-kHz) stimulation as an alternative to amplitude-modulated kilohertz (AM-kHz) for phasic neural activation, showing comparable performance in computational models and experimental data.

Titanium and platinum coatings reduce inflammation induced by gold on subretinal prosthesis

This study shows that gold coatings on subretinal implants cause retinal inflammation and neuronal loss, while platinum and titanium coatings reduce these effects, enabling better visual resolution implants.

A Microfluidic Platform for Spatiotemporal Dissection of Neurodegeneration Across Hierarchical Human Neural Circuits

This paper introduces a microfluidic platform to study neurodegeneration in human neural circuits, identifying early electrophysiological biomarkers of disease progression.

Multi-Layer Brain-Mimicking Phantom for Replicating Dura and Pia Membrane Dimpling and Rupture Properties During Neural Interface Implantation

This paper develops a multi-layer brain-mimicking phantom to replicate dura and pia membrane dimpling and rupture properties during neural interface implantation, validated against in vivo rat data.

Photopatterned spatiotemporal organisation and in situ differentiation of 3D human cortical networks

This paper introduces a 3D human cortical network model using photopatterning to enable spatially controlled differentiation and maturation of neurons and glia, revealing developmental transitions and synaptic integration.

A voltage-step method for detecting high-frequency transient current components in deep brain tissue: preliminary in vivo measurements in rats

The paper presents a voltage-step method to measure high-frequency transient currents in deep brain tissue, showing differences between catecholaminergic regions and cortical tissue in rats.

P-DOpE probes reveal local amplification of phasic noradrenergic release in the hippocampus

The paper introduces a P-DOpE probe that combines optogenetics and electrophysiology for in vivo monitoring, showing it amplifies noradrenergic signaling in the hippocampus under specific conditions.

Miniaturized wireless bioelectronics for electrically driven biohybrid robots

This paper develops a wireless bioelectronic stimulator to drive biohybrid robots in cell culture, achieving autonomous motion and stable cell function.

Long-term neuron tracking reveals balance of stability and plasticity in functional properties

This study tracks individual neurons over time to show that while spike waveforms remain stable, some functional properties like firing rates and tuning can change, indicating a balance between neural stability and plasticity.

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation

This study shows that astrocytes and neurons respond differently to intracortical microstimulation, with astrocytes showing spatially heterogeneous and temporally variable responses.

Exploring the functionality of market-available tools for neural recording

The paper evaluates a modular neural recording platform built from commercial components, showing it can recover LFP-like waveforms and detect spikes, though with signal quality issues.

A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces

This paper introduces a flexible thin-film transistor platform for active neural sensing, demonstrating long-term stability and high channel count scalability in vivo.

Electrolytic-Microbubble Dynamics Delineate Safety Thresholds During Intracortical Microstimulation with Flexible Neural Interfaces

This study identifies safety thresholds for intracortical microstimulation by analyzing bubble dynamics and vascular leakage in awake mice.

Functional Somatotopy of Lumbar Dorsal Rootlets and its Role in Selective Recruitment via Lateral Spinal Cord Stimulation

This study shows that lateral spinal cord stimulation (LSCS) selectivity is limited by the coarse organization of lumbar dorsal rootlets, not electrode design, and suggests improving electrode placement may enhance percept localization.

Examining Action Potential Waveform Diversity in Neuronal Populations of Midbrain Organoid Models

This study uses electrophysiological recordings from midbrain organoids to cluster action potential waveforms and identifies three categories, one potentially from dopaminergic neurons.

A modular, high-bandwidth, bidirectional implantable device for neural interrogation

The paper introduces a modular, high-bandwidth, bidirectional implantable device for neural interfacing, validated in vivo in sheep.

Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation

This study introduces Adaptive Charge Modulation (ACM) for spinal cord stimulation, achieving focal activation at deep tissue sites with reduced surface activation and muscle co-activation.

Identification of Direct and Network-Mediated Activation of Retinal Ganglion Cells from Visually Evoked Potentials Using Machine Learning

The paper develops a machine learning model to identify retinal ganglion cell activation pathways from visually evoked potentials, avoiding the need for toxic synaptic blockers.

Density-based longitudinal neuron tracking in high-density electrophysiological recordings

DANT improves longitudinal neuron tracking in high-density electrophysiological recordings by combining density-based clustering and motion correction to increase match yield and reduce false negatives.

Distinguishing Photoacoustic and Photothermal Neuron Stimulation Through Quantitative Mapping Spatiotemporal Field Evolution

This paper distinguishes photoacoustic and photothermal neuron stimulation by mapping their spatiotemporal field evolution, finding neurons are more responsive to photoacoustic stimulation.

A Fully Endovascular Neural Interface

This paper introduces a fully endovascular neural interface that delivers electrical stimulation and recording through a microcatheter, demonstrating blood pressure modulation in rabbits.

A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation

This paper introduces a hybrid micro-ECoG array for multi-scale brain activity recording and functional mapping across species.

KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking

KIASORT improves spike sorting by tracking neuron-specific drift without relying on probe geometry, outperforming Kilosort4 in benchmarks.

In Situ Graphene-Seq: Spatial Transcriptomics and Chronic Electrophysiological Characterization of Tissue Microenvironments

This paper introduces in situ graphene-seq, a platform integrating chronic electrophysiology with spatial transcriptomics to analyze tissue microenvironments, showing how spatial heterogeneity affects cell function and gene expression.

Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics

The paper introduces Neuropixels Opto probes that combine high-resolution electrophysiology with optogenetics for spatially addressable neuronal manipulation and recording.

Opening the black box: a modular approach to spike sorting

The paper introduces a modular framework for spike sorting that allows individual algorithmic steps to be benchmarked and optimized, improving performance on simulated data and matching real data results.

Surgical Protocol for a Large, Resealable Cranial Window Enabling Longitudinal, Multi-Modal Electrophysiology Recordings of the Mouse Default Mode Network

This paper describes a surgical protocol for creating a large, resealable cranial window in mice to enable long-term, multi-modal electrophysiological recordings of the Default Mode Network.

Flytrap-Inspired Mesh-Trap Bioelectronics for Full Spherical Electrophysiological Interrogation of 3D Tissues

This paper introduces a bioelectronic mesh system for comprehensive electrophysiological monitoring of 3D tissues and assembloids, enabling long-term stable recordings and high-throughput analysis.

Neural population dynamics of direct electrical stimulation of neocortex

This study investigates how electrical stimulation of the neocortex affects neural activity and perception in mice, finding that anatomical structure and spatiotemporal patterns, rather than spike counts, determine physiological and perceptual outcomes.