Viral Infections and Vectors

The hyper-attenuated RVFV 40Fp8 strain can be safely administered to pregnant ewes to protect them from a virulent challenge

This study evaluates the safety and protective efficacy of the RVFV-40Fp8 strain in pregnant ewes, showing no fetal damage and protection against a virulent challenge.

Protocol for the production of an Arenavirus and Hantavirus host-pathogen database: Project ArHa.

This paper proposes the development of a database (ArHa) integrating host-pathogen dynamics and human disease data for Arenaviruses and Hantaviruses to improve risk assessments and public health interventions.

Focal persistence and phylodynamics of Heartland virus in Georgia

The paper identifies a focal site of Heartland virus in Georgia, generates new genome sequences, and finds regional clustering and recent spread of the virus.

Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex

The paper describes the structure and immunogenicity of a stabilized CCHFV heterotrimeric glycoprotein complex and shows it provides 40% protection against viral challenge in mice.

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.

Seoul orthohantavirus evades innate immune activation inreservoir endothelial cells

This study investigates how Seoul orthohantavirus evades innate immune activation in reservoir endothelial cells, finding that viral replication prevents immune recognition motifs from being exposed.

Circulating mucosal-like IgA responses associate with severity of Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome

The paper examines circulating mucosal-like IgA responses in Puumala orthohantavirus infection and finds they correlate with AKI severity and pro-inflammatory effects.

Orthohantavirus Diversity in Central-East Argentina: Insights from Complete Genomic Sequencing on Phylogenetics, Geographic patterns and Transmission scenarios.

This study reports complete genomic sequences of orthohantaviruses from Central-East Argentina, revealing phylogenetic relationships, geographic distribution patterns, and transmission dynamics.

Genomic and phenotypic characterization of an Oropouche virus strain implicated in the 2023-24 large-scale outbreak in Brazil

The paper characterizes an Oropouche virus strain from the 2023-24 outbreak in Brazil, showing its ability to infect non-human primates and establishing lineage origins from the Amazonas region.

Cellular N-myristoyl transferases Are Required for Mammarenavirus Multiplication

This study shows that NMT inhibition reduces mammarenavirus replication by impairing Z protein budding and GP2 fusion activity.

Machine Learning Reveals Key Glycoprotein Mutations and Rapidly Assigns Lassa Virus Lineages

The paper identifies key glycoprotein mutations in Lassa virus lineages and develops a tool for rapid lineage classification.

Vaccine strains of Rift Valley fever virus exhibit attenuation at the maternal-fetal placental interface

This study shows that vaccine strains of Rift Valley fever virus replicate less in placental tissues compared to wild-type strains, suggesting attenuation at the maternal-fetal interface.

Do NSm virulence factors in the Bunyavirales viral order originate from Gn gene duplication?

The paper predicts the structure of NSm proteins in Bunyavirales viruses and finds structural similarity to Gncyto domains, suggesting gene duplication events in their evolution.

Choclo virus (CHOV) recovered from deep metatranscriptomics of archived museum tissues

The paper recovers a nearly complete Choclo virus genome from archived museum tissues using deep metatranscriptomics and reference-guided assembly.

Phylogeographic reconstruction of the emergence and spread of Powassan virus in the northeastern United States

This study reconstructs the emergence and spread of Powassan virus lineage II in the northeastern U.S. using genomic data, finding a south-to-north dispersal pattern and population growth.

Efficient rescue of a newly classified Ebinur lake orthobunyavirus with GFP reporter and its application in rapid antiviral screening

The paper rescues a recombinant Ebinur lake orthobunyavirus with a GFP reporter for antiviral screening and identifies ribavirin as an inhibitor.

Heterogeneity of Rift Valley fever virus transmission potential across livestock hosts, quantified through a model-based analysis of host viral load and vector infection

Inference of Rift Valley Fever pathogenesis in Bos taurus using a gene co-expression network

This study constructs a gene co-expression network to identify genes and regulatory motifs involved in Rift Valley Fever pathogenesis in cattle.

Unsupervised Clustering characterizes the CPG dinucleotides distribution of the Andes hantavirus

The paper uses unsupervised clustering to analyze CpG dinucleotide distribution in orthohantaviruses, identifying four sub-groups and highlighting Andes virus's unique CpG odds ratio.

Complete Coding Genome Sequence for a Novel Multicomponent Kindia Tick Virus Detected from Ticks Collected in Guinea

The paper presents the complete coding genome sequence of a novel multicomponent tick virus, KITV/2017/1, detected in ticks from Guinea.

Oropouche virus cases identified in Ecuador using an optimised rRT-PCR informed by metagenomic sequencing

The paper optimizes an rRT-PCR assay for Ecuadorian OROV lineage, identifying five additional cases in febrile patients.

Rift Valley fever virus minigenome system for investigating the role of L protein residues in viral transcription and replication

A comparative genome analysis of Rift Valley Fever virus isolates from foci of the disease outbreak in South Africa in 2008-2010

The paper analyzes genome sequences of Rift Valley Fever virus isolates from South Africa's 2008-2010 outbreaks to study their evolutionary dynamics and reassortment patterns.

Bioinformatics analysis for L polymerase homology of arenaviruses

The paper uses bioinformatics analysis to identify similarities between arenavirus L polymerase and other hemorrhagic fever viruses in GenBank.

Genetic dissection of Rift Valley fever pathogenesis: Rfvs2 on mouse chromosome 11 enables survival to acute-onset hepatitis

This study identifies Rvfs2 as a genetic locus that restricts RVFV replication and enables survival from acute liver disease in mice.

Genetic variability in the promoter region of TNF-α gene in the reservoir of Junin virus, Calomys musculinus (Rodentia, Cricetidae)

The paper examines genetic variability in the TNF-α promoter region across three populations of Calomys musculinus, finding differences in variability and selection signatures linked to epidemiological history.

Genome Wide Computational Prediction of miRNAs in Kyasanur Forest Disease Virus and their Targeted Genes in Human

The paper predicts miRNAs in Kyasanur Forest Disease Virus and identifies their target genes in humans, finding potential roles in hemorrhagic fever and neurological issues.