Viral Infections and Vectors

Viral RNA persistence in sheep tissues following acute Crimean-Congo hemorrhagic fever virus infection

This study shows that CCHFV persists in sheep tissues after viremia clearance, with sporadic replication products detected, suggesting potential for viral reactivation.

Finding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccine

This study identifies key glycoprotein residues that enhance the efficacy of a CCHFV vaccine by modulating cleavage and fusogenicity in animal models.

Integrated in vivo and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy

This study shows favipiravir suppresses OROV replication and disease in hamsters, preventing neuroinvasion and pathogenic host responses through transcriptomic analysis.

Sirtuin 1 Is Required for Optimal Mammarenavirus Multiplication

This study identifies Sirt-1 as a host factor required for optimal LCMV multiplication and suggests repurposing Sirt-1 inhibitors as antivirals.

Expanded protocadherin-1 usage reveals a broader hantavirus entry landscape

This study identifies expanded protocadherin-1 usage by hantaviruses and shows differential neutralization by antibodies.

Mutations that positively affect Bandavirus glycoprotein function on VSV vectored vaccines

This paper identifies a mutation that enhances the efficacy of a VSV-based vaccine against SFTSV and develops a similar vaccine for HRTV, showing improved immune responses and protection.

Jamestown Canyon virus rapidly adapts to mosquito cells through multiple M segment mutations

This study shows Jamestown Canyon virus adapts to mosquito cells through multiple M segment mutations, enhancing replication efficiency but no single mutation fully reproduces the natural adaptation phenotype.

Powassan virus infects mouse testes with phagocytic cells playing a protective role

This study shows that Powassan virus infects mouse testes and that phagocytic cells help limit viral infection in the male reproductive tract.

Reverse genetics and comparative pathogenesis of Lone star virus.

This study generates recombinant Lone star virus (LSV) and compares its pathogenesis with related bandaviruses in mice, revealing differences in disease severity and immune response.

Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025

This study shows Rift Valley fever virus lineage C circulates persistently in Rwanda through local transmission, not repeated introductions, based on whole-genome sequencing of livestock samples from 2022-2025.

Hantavirus stability and inactivation

This study investigates the stability of hantaviruses under various environmental stresses and evaluates inactivation methods, finding that they are stable under some conditions but can be effectively inactivated by common methods.

Development and qualification of an enzyme-linked immunosorbent assay to detect human serum immunoglobulin G reactive to multiple lineages of Lassa virus nucleoprotein

This paper develops and validates an ELISA to quantify anti-LASV-NP IgG in human serum, demonstrating sensitivity, precision, and specificity for LASV epidemiology and vaccine development.

Oropouche virus causes acute hepatitis in mice controlled by Type I interferons

This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.

Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony

The paper describes the eradication of a Puumala hantavirus outbreak in a bank vole colony using maternal antibodies to protect offspring and eliminate the virus from subsequent generations.

Crimean-Congo Haemorrhagic Fever Virus Circulates within Broad Ecological Networks of Ticks and Vertebrates

This paper models the distribution of Crimean-Congo haemorrhagic fever virus by integrating climatic, tick, and vertebrate data, showing that ecological interactions, not climate alone, determine its range.

Contact networks of small mammals highlight potential transmission foci of Mammarenavirus lassaense

The paper examines small mammal contact networks in Sierra Leone to identify potential transmission foci of Mammarenavirus lassaense, finding that land use affects rodent-rodent interactions and seroprevalence patterns.

Sensitivity analysis of factors influencing the ecology of mosquitoes involved in the transmission of Rift Valley fever virus

This paper uses a mathematical model to analyze how ecological factors influence mosquito populations involved in Rift Valley fever transmission, identifying key parameters affecting mosquito abundance and disease risk.

Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups

The paper isolates human monoclonal antibodies against SFTSV Gn, identifies four neutralizing epitope groups, and validates their neutralization through structural analysis.

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice

The paper develops a mouse-adapted Yezo virus model that causes lethal infection in immunocompetent mice, identifies key mutations enhancing virulence, and evaluates antiviral efficacy.

Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat's body surface

This paper develops a non-invasive method to detect RNA viruses in cats using sebum, demonstrating its effectiveness for FIV and SFTSV detection comparable to blood tests.

P-BODY AND CYTOSKELETON REMODELING BY ORTHOHANTAVIRUSES.

This study uses advanced imaging to analyze how orthohantaviruses alter P-bodies and the cytoskeleton during infection, revealing spatial correlations and degradation patterns of viral RNAs.

Characterization of neural infection by Oropouche orthobunyavirus

This study characterizes Oropouche orthobunyavirus replication in neural cells and brain slices, showing cytokine production and providing a model for studying viral neuropathogenesis.

Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids

This study shows that Oropouche virus infects human neural progenitor cells and brain organoids, causing proliferation arrest and loss of neural rosette organization.

Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication

This paper shows halofuginone inhibits mammarenavirus replication by targeting prolyl-tRNA synthetase, leading to translation inhibition and reduced viral budding.

THE LASSA VIRUS FUSION DOMAIN HAS STRUCTURAL PLASTICITY AND EXPLOITS BIS(MONOACYLGLYCERO)PHOSPHATE FOR FUSION

This study investigates the structural plasticity of the Lassa virus fusion domain and its interaction with BMP lipids during membrane fusion.

Utility of recombinant envelope domain III as a diagnostic antigen for the specific detection of Kyasanur Forest Disease

This paper develops a specific ELISA test for Kyasanur Forest Disease using recombinant envelope domain III protein as an antigen, showing high specificity and sensitivity.

A century-old museum sample reveals abandavirus with modern day presence in northernEuropean bats

This study recovers an ancient Bandavirus genome from a 1919 bat sample and identifies its modern presence in European bats, showing its ability to block interferon induction.

Structure and function of the nairovirus cap-snatching endonuclease

This study characterizes the structure and function of nairovirus cap-snatching endonucleases, revealing a unique two-metal-ion mechanism and identifying potent inhibitors.

Lrp1 facilitates infection of neurons by Jamestown Canyon virus

This study identifies Lrp1 as a host factor required for Jamestown Canyon virus infection of neurons and shows it is shared by other bunyaviruses.