Planarian Biology and Electrostimulation

Overview of the expression of key regeneration genes in embryo development and matured tissues in Axolotl (Ambystoma mexicanum)

This report examines the expression of 70 regeneration-related genes in axolotl embryos, regeneration, and adult tissues, identifying approximately 3 genes expressed exclusively during regeneration.

A regulatory program for initiation of Wnt signaling during posterior regeneration

This study identifies wnt-3 as a key gene initiating Wnt signaling during posterior regeneration in the acoel worm Hofstenia miamia, revealing its role in stem cell proliferation and posterior identity establishment.

Transcriptomic analysis of bone and fibrous tissue morphogenesis during digit tip regeneration in the adult mouse

This study identifies gene regulatory networks driving digit tip regeneration in mice, showing level-dependent differences in gene expression and tissue regrowth.

Identification of rare transient somatic cell states induced by injury and required for whole-body regeneration

Cell-type diversity and regionalized gene expression in the planarian intestine revealed by laser-capture microdissection transcriptome profiling

This study uses laser-capture microdissection and RNA-Seq to analyze the planarian intestine's transcriptome, revealing cell-type diversity and regionalized gene expression.

von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration

The paper identifies vwde expression as a conserved feature of blastemas involved in appendage regeneration across species and shows its functional requirement in regeneration.

Canonical Wnt Signaling is Involved in Anterior Regeneration of the Annelid Aeolosoma viride

This study investigates the role of canonical Wnt signaling in anterior regeneration of the annelid Aeolosoma viride, finding that Wnt pathway activation and inhibition affect regeneration outcomes.

Epigenetic immune-modulation by Histone Deacetylase Activity (HDAC) of tissue and organ regeneration in Xenopus laevis

This study investigates how HDAC activity epigenetically modulates myeloid cell behavior and regenerative ability in Xenopus tadpoles during tail regeneration.

Cellular heterogeneity and lineage restriction during mouse digit tip regeneration at single cell resolution

The paper uses single-cell RNA sequencing to analyze mouse digit tip blastema cells, identifying lineage-restricted progenitors and a novel regeneration-specific gene, Mest.

Somatic drift and rapid loss of heterozygosity suggest small effective population size of stem cells and high somatic mutation rate in asexual planaria

The paper estimates the effective population size and somatic mutation rate in asexual planarians using population genetic models and pedigree data.

Integrative Analysis of Axolotl Gene Expression data from Regenerative and Wound Healing Tissues

This study integrates microarray and RNA-Seq data from axolotl limb regeneration to identify differentially expressed genes and validate their expression patterns.

Transcriptome and Proteome analysis of Hemidactylus frenatus during initial stages of tail regeneration

This study identifies genes and proteins involved in tail regeneration in Hemidactylus frenatus using transcriptomics and proteomics, finding 36 commonly expressed genes/proteins and associations with several signaling pathways.

Expressing of Cytochrome-c, ADAM 17, Wnt-5a, and Hedgehog gene during the tissue regeneration of digit tip mice (Mus musculus) var Swiss Webster post amputation

The paper examines the expression of Cytochrome-c, ADAM 17, Wnt-5a, and Hedgehog genes during digit tip regeneration in mice, showing their roles in specific phases of tissue regeneration.

Region-specific regulation of stem cell-driven regeneration in tapeworms

The paper identifies region-specific regulation of stem cell-driven regeneration in tapeworms, showing that extrinsic signals from the head and neck control regeneration without stem cell restriction to the neck.

Ongoing repair of migration-coupled DNA damage allows stem cells to reach wound sites

The paper shows that migrating stem cells in planarians experience DNA damage, which is repaired to allow migration to wound sites.

Injury stimulates stem cells to resist radiation-induced apoptosis

The paper shows that tissue injury can protect stem cells from radiation-induced apoptosis by inducing a transient protective signal from dying cells.

Comparison of Gene Expression During Early Phases of Limb Regeneration Between Regeneration-permissive Neotenic and Regeneration-deficient Metamorphic Axolotl

The paper compares proteomic profiles of early limb regeneration in neotenic and metamorphic axolotls to identify differences in protein expression and pathways associated with regenerative capacity.

Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa

The paper analyzes sea star larval regeneration to identify conserved molecular processes of whole-body regeneration across metazoans.

Smed-egfr-4 is required for planarian eye regeneration

This study shows that Smed-egfr-4 is required for the final differentiation of eye cells in planarians, not their specification, and supports the idea that EGFR pathways regulate progenitor differentiation.

General characterization of regeneration in Aeolosoma viride

This study characterizes the regeneration process in Aeolosoma viride, showing high cell proliferation and blastema formation, and identifies cell proliferation as critical for regeneration.

Effects of Ivermectin exposure on regeneration of D. dorotocephala planaria

This study examines the effects of ivermectin on regeneration in D. dorotocephala planaria, finding patterning abnormalities and delayed regeneration.

Morphological, cellular and molecular characterization of posterior regeneration in the marine annelid Platynereis dumerilii

This study characterizes posterior regeneration in Platynereis dumerilii, showing a rapid, reproducible process with specific stages and local blastema formation.

Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

The paper shows that positional information determines organ regeneration sites but not tissue maintenance in planarians, as homeostasis can occur independently of precise positional cues.

A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs

The paper identifies a nuclear hormone receptor and lipid metabolism axis critical for reproductive organ maintenance and regeneration in planarians.

A novel flatworm-specific gene family implicated in reproduction in Macrostomum lignano

The paper re-analyzes germline transcriptional signatures in M. lignano and identifies a novel flatworm-specific gene family essential for sperm production.

Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea

The paper identifies transcriptional regulators of epidermal lineage differentiation in planarians and discovers novel secreted organelles.

Insights into regeneration from the genome, transcriptome and metagenome analysis of Eisenia fetida

The paper presents genome, transcriptome, and metagenome data from Eisenia fetida to study regeneration dynamics, identifying differentially expressed genes and microbial communities.

The Abrogation Of Condensin Function Provides Independent Evidence For Defining The Self-Renewing Population Of Pluripotent Stem Cells

The paper shows that condensin I is essential for planarian stem cell maintenance and that only sigma-neoblasts can self-renew.

Yorkie is required to restrict the injury responses in planarians

This study shows that yorkie restricts hyper-activated injury responses in planarians, ensuring proper scaling of regenerative outcomes.

PHRED-1 Is A Divergent Neurexin-1 Homolog That Organizes Muscle Fibers And Patterns Organs During Regeneration

This study identifies PHRED-1 as a gene essential for muscle regeneration and organ patterning in planarians, showing its role in structural integrity and intestinal branching.