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This study reveals how bile salts induce ToxS homodimerization, providing a structural model for ToxRS system activation in Vibrio pathogens.

The paper compares catalytic efficiencies of metabolic enzymes across species, finding pathway-specific and context-dependent patterns rather than a universal trend.

The paper compares urinary proteome modifications between patients with different HbA1c levels and healthy controls, identifying distinct peptide changes associated with elevated HbA1c.

The paper presents cryo-EM structures of Photosystem I with alternative quinones, revealing asymmetry in quinone binding and exchange.

The paper presents cryo-EM structures of anti-Z-DNA antibodies bound to Z-DNA, revealing their recognition mechanism and lack of B-to-Z transition induction.

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

This paper designs a protein family that binds and senses small molecules using deep learning and physics-based methods, achieving nanomolar sensitivity for cortisol.

This study optimizes LC-MS detection of retinoids in cerebrospinal fluid, showing that tailored parameters are needed for reliable identification in low-abundance biofluids.

This study determines the structure of Mgm101, a RAD52 homolog, and reveals its single-strand annealing mechanism using cryo-EM and mass spectrometry, showing it anneals ssDNAs on the same ring in cis.

The paper uses direct RNA sequencing to analyze rRNA modifications in E. coli ribosome assembly intermediates and mature subunits, showing stress-dependent reprogramming of specific modifications.

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

This study investigates how uridylation mediates RNA decay in Drosophila by showing how Tailor generates oligo(U) intermediates and how Dis3l2 decodes these to initiate decay.

This study investigates how pathogenic mitochondrial tRNA variants impair RNA processing by affecting 5' leader removal and downstream tRNA release.

This study uses holographic imaging to show that Bovine Serum Albumin phase separation depends on higher-order oligomers and is tunable by pH.

This study investigates the ISG15-USP18-STAT2 inhibitory complex's structure and function using AlphaFold and biochemical methods, revealing critical residues and patient mutations affecting its interaction.

The paper investigates how the microenvironment within biomolecular condensates affects reaction kinetics using protein ligation as a model, identifying effective concentration, hydrophilicity, and water activity as key factors.

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

This study shows plant-derived soft electrophiles increase pro-resolving oxylipins in a Drosophila Parkinson's model, suggesting potential therapeutic benefits for neuroinflammation.

This study uses time-resolved serial crystallography to track ligand binding and conformational changes in T4 lysozyme, revealing a diffusion-limited process leading to a dominant conformational state.

This study engineers a dimeric single-domain antibody that improves detection and neutralization of amyloid-β oligomers, showing enhanced specificity and efficacy compared to its monomeric form.