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Multilayer-assembled microfluidic chip with Tesla-valve channels: Combined biochemical gradient and mechanical stiffness interface for 3D SKOV3 cell culture

This paper develops a multilayer microfluidic chip with Tesla-valve channels to simulate tumor microenvironments by combining biochemical gradients and mechanical stiffness for 3D SKOV3 cell culture.

Modular PEGylation Confers Reduced Immune-Cell Uptake and Enhanced Pharmacokinetic Performance to Encapsulin Protein Nanocages

This study shows that modular PEGylation of encapsulin nanocages reduces macrophage uptake and extends circulation time in mice.

First evidence for TIGR-Tas activity in a photosynthetic eukaryote

This study demonstrates TIGR-Tas activity in the green alga Chlamydomonas reinhardtii, showing DNA cleavage and indel formation, but notes low efficiency.

Lateralised Transmission of Beta Oscillations From Cortex to Muscle During Movement Cancellation Reflects Selective Motor Inhibition

The paper examines beta oscillation transmission from cortex to muscle during movement cancellation, finding effector-specific peripheral synchronisation that reflects motor inhibition.

Generation and application of human pluripotent stem cells derived peri-nervoids

This study generates human pluripotent stem cell-derived Schwann cells and neural organoids to create a nerve-like construct, showing improved regeneration in mouse models.

Bioplastic Production from simulated 100% in situ Mars resources

This study demonstrates the production of PHA bioplastic from simulated 100% Martian resources using engineered microbes.

Walking speed can be modulated on an adaptive split-belt treadmill

The paper demonstrates that walking speed can be modulated on an adaptive split-belt treadmill through unilateral modifications.

Adaptations of the pregnant murine heart to pre-existing hypertension

This study examines how pregnancy affects cardiac function in mice with pre-existing hypertension, finding that pregnancy can mitigate some hypertension-related cardiac impairments.

Broadband backscattering confocal microscopy enables label-free 3D live cell nanoscale sensitive imaging

This paper introduces broadband backscattering confocal microscopy (BBCM) for label-free 3D live cell imaging with improved contrast and size sensitivity.

Chemically modified CRISPR enzymes for multi-organ genome editing in vivo

This paper introduces PERCEPT, a CRISPR delivery platform that enables multi-organ genome editing in vivo by chemically modifying CRISPR enzymes for targeted and efficient delivery.

Sound from Ultrasound: Characterization of a MEMS-based personal-audio device in human temporal bones

This study characterizes ultrasonic acoustic output from a MEMS-based audio device in human temporal bones, measuring sound pressure levels and vibration velocities to assess biological exposure.

A custom two-in-one HIST and line-scanning confocal excitation module

This paper introduces a reconfigurable microscopy module that combines HIST and line-scanning confocal techniques for versatile fluorescence imaging.

Direct electrochemical cortisol detection via transition-resolved interrogation at a defect-engineered graphene interface

This paper develops a method for direct electrochemical cortisol detection using a defect-engineered graphene interface and transition-resolved interrogation, achieving sensitive and selective detection in biological fluids.

Microglia modulate concussion biomarkers and cognitive recovery in male mice

This study shows microglia influence concussion recovery and identifies EV miRNA biomarkers affected by microglial presence.

Cell painting with amphiphile-protein conjugate vaccines drives B cell activation and germinal center priming to enhance humoral immunity

Extraocular Electrical Stimulation Activates Retinal Ganglion Cells In Vivo

This study shows that asymmetric charge-balanced electrical stimulation more effectively activates retinal ganglion cells in vivo at lower amplitudes than symmetric waveforms.

Multiscale structural control of airflow, diffusion and heat transfer in non-fungus farming termite mounds

This study examines how structural features of termite mounds affect airflow, diffusion, and heat transfer across multiple scales.

Precision cooling assists electrical stimulation: Breaking selectivity barriers in nerve control

The paper shows that local cooling improves the selectivity of electrical stimulation in nerves by reducing unwanted activity and enabling directional control.

Human skin fibrosis with iPSC-derived organoids reveals RUNX2-mediated fibroblast reprogramming

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

Soft-Robotic Magnetic Microfluidic Catheter for Delivery of Aqueous-Based Dual-Component Embolic Formulations

This paper introduces a soft-robotic microfluidic catheter delivering a water-based hydrogel for embolization, demonstrating controlled delivery and drug targeting in multiple animal models.