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Postprocessing of P300 Speller Output with a Large Language Model

This paper uses large language models to improve P300 speller output by reducing errors from fewer stimulus repetitions, enhancing communication efficiency.

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

This paper develops a nanoparticle platform to target TLR3 agonist to antigen-presenting cells, improving cancer immunotherapy safety and efficacy by reducing systemic toxicity and enhancing tumor targeting.

3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array

This paper introduces a 3D-PCM system with expanded field of view and high resolution for real-time cavitation detection during laser lithotripsy.

Lipid Network Crosslinked Hydrogels: Controlling MaterialDynamics Across Multiple Length Scales Through Lipid Movement

This paper introduces LINC hydrogels that use lipid mobility to control material dynamics across multiple length scales, showing that neural progenitor cells respond to nanoscale ligand dynamics.

Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

Confocal Raman Microscopy-Guided Optimization of Early Otic Differentiation from Human Pluripotent Stem Cells

The paper optimizes BMP4 concentrations for otic differentiation from hiPSCs using Raman microscopy to monitor molecular changes and improve reproducibility.

IROP: Ionic Regulation of Permeation for High-Yield AAV Purification

The paper introduces IROP, a new purification method for AAV that uses ionic strength modulation to achieve high yield and impurity removal.

FOLR1-targeted Actinium-225-based Alpha-particle Therapy Eliminates Ovarian Cancer

This study demonstrates that FOLR1-targeted Actinium-225 alpha-particle therapy effectively treats ovarian cancer with high tumor regression and survival rates while minimizing toxicity.

A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces

This paper introduces a flexible thin-film transistor platform for active neural sensing, demonstrating long-term stability and high channel count scalability in vivo.

Semi-quantitative Classification of HIV-1 Nucleic Acids Using ResNet Image Analysis of Discretized Isothermal Amplification Reactions in a Microfluidic Chip

This paper develops a machine learning approach to semi-quantitatively classify HIV-1 nucleic acids using image analysis of isothermal amplification reactions in microfluidic chips, achieving high accuracy across a wide concentration range.

Generation of Cellular Biofactories for Scalable Production of Surface-Engineered Extracellular Vesicles via CRISPR Genome Editing

This study develops CRISPR-Cas9 engineered HEK293T cells for stable production of surface-engineered extracellular vesicles, showing improved consistency and scalability compared to transient transfection.

From Body Hulls to Musculoskeletal Models: Personalized Inertial Parameter Estimation

This paper develops a method to estimate personalized musculoskeletal inertial parameters using body hulls from smartphone images, improving accuracy over generic models in gait analysis.

Zero-shot design of drug-binding proteins via neural selection-expansion

This paper introduces a method using two neural networks to design drug-binding proteins with high affinity, surpassing current state-of-the-art methods.

Force sharing between plantarflexor muscles in sheep during treadmill gait

This study examines force sharing between plantarflexor muscles in sheep during treadmill gait, finding that both muscles increase force with speed and incline, but the superficial digital flexor consistently produces greater absolute force than the medial gastrocnemius.

Catalytic rewiring of RuvC-II catalytic site activates trans-cleavage in Fanzor2

This study shows that catalytic rewiring of Fanzor2's RuvC-II site activates trans-cleavage, enabling new diagnostic applications.

A Universal Free-Degree Orientation Extrusion Head Enables Conformal and Non-Planar Bio-Additive Manufacturing toward Adaptive and Future-Ready Bioprinting

This paper introduces a new extrusion head for 3D bioprinting that enables conformal and non-planar printing by allowing orientation freedom without external actuation.

Cervical spinal cord stimulation disrupts proprioception yet improves voluntary arm reaching

This study shows that cervical spinal cord stimulation impairs proprioception but improves voluntary arm reaching in post-stroke patients.

Engineering of CAR-less lentiviral vectors via ER retention-mediated CAR blockade

The paper develops CLEAN-V, a lentiviral vector system that blocks CAR protein incorporation into viral particles, enabling safer in vivo CAR-T therapy without compromising functionality.

Substrate stiffness and viscoelasticity influence fibroblast senescence

This study shows that hydrogel stiffness and viscoelasticity influence fibroblast senescence, with viscoelasticity uniquely promoting senescence even without genotoxic stress.

Self-Calibrated Hyperspectral Neural Radiance Fields for 3D Reconstruction of Bone and Bone Analogues

This paper introduces BoNeRF-HS, a self-calibrated hyperspectral neural radiance field for 3D reconstruction of bone and bone analogues, achieving better reconstruction quality and surface detail preservation.