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Super-Resolution Macrophage Imaging via Ultrasound Localization Microscopy and Blinking Nanodroplets

This paper introduces a super-resolution ultrasound imaging method using blinking nanodroplets to track macrophages in vivo with improved spatial resolution.

A mathematical model of osteocyte network control of bone mechanical adaptation

This paper develops a one-dimensional computational model of bone mechanical adaptation based on osteocyte network dynamics and signal propagation, revealing new adaptation behaviors and thresholds.

Integrating Diffusion and Liquid AI Models for Predicting Peptide Affinity from mRNA Display Selections

The paper predicts peptide binding affinities using machine learning models trained on mRNA display data, identifying high-affinity peptides with single-digit picomolar affinities.

Granular Extracellular Matrix (gECM) Hydrogels Enable Distinct Composition and Mechanics Across Tissue Types for Translation

This study develops and characterizes granular ECM hydrogels for five tissues, showing they retain shape, stability, and support tissue-specific cellular activity.

Cell-cultured PDMS vascular model to allow placement of implant devices

This paper develops a 3D in vitro vascular model using PDMS and endothelial cells to study stent-induced mechanical effects and endothelialization.

Programmable DNA Origami Caps for Site-Selective Functionalization of Microtubule Tips and Lattice Defects

This paper develops DNA origami caps to selectively functionalize microtubule tips and lattice defects, enabling controlled cargo capture and dynamic visualization.

Decoding peripheral stimulation from cortical and spinal recordings reveals complementary sensorimotor information

This study decodes peripheral stimulation from spinal and cortical recordings, showing that spinal signals provide complementary information to cortical EEG for mixed stimulation tasks.

Adeno-Associated Virus Co-Precipitation with Extracellular Vesicles for Genome Editing in Rodent Embryo

This paper describes a method to co-isolate AAV with extracellular vesicles for efficient genome editing in rodent embryos, achieving higher viability and targeting efficiency compared to traditional purification methods.

Z-TAC enables custom and combinatorial degradation of cell surface proteins

Z-TAC converts IgG antibodies into cell-surface protein degraders, enabling efficient and sustained degradation of multiple receptors and receptor combinations.

Electrical stimulation directs formation of perfused vasculature in engineered tissues

This study shows electrical stimulation promotes the formation of functional, perfusable vasculature in engineered tissues by inducing endothelial cell hyperpolarization via KV channels.

Flowable Grafts Made from Granular Extracellular Matrix (gECM) Hydrogels Promote Integrative Repair of Articular Cartilage in a Large-Animal Model

A granular extracellular matrix hydrogel implanted in a goat condyle provided a robust repair, filling the defect tissue with integrated, hyaline-like cartilage at 12 months.

A Computational Functional Tissue Unit of the Human Myometrium for In Silico Study of Gestational Excitability and Pathophysiology

The paper develops a multi-scale model of the human myometrium to study gestational excitability and pathophysiology, showing how tissue-level contractions emerge from single-cell electrophysiology and how inflammation can lead to preterm labour.

EFFICIENT EXPANSION OF NK-92 CELL LINE USING A NOVEL LOW-SHEAR STRESS BIOREACTOR

This paper describes a novel low-shear stress bioreactor for expanding NK-92 cells, showing improved cell growth and viability compared to traditional methods.

Engineering a hybrid 3D construct for bone regeneration to promote simultaneous pre-vascularization and osteogenic differentiation in vitro

This study develops a hybrid 3D construct that supports both vascular network formation and osteogenic differentiation in vitro using tailored hydrogel chemistry and cell co-culture.

Functionalization of Gold Surfaces with Dithiobis(succinimidyl propionate) for Immobilization of Fetuin-A and Assessment of the Attachment and Proliferation of Osteoblast-like Cells

This study immobilizes fetuin-A on gold surfaces using DSP and assesses its effect on osteoblast-like cell attachment and proliferation, finding reduced proliferation compared to fibronectin.

Defining characteristics of mesenchymal stem cell-derived matrix-bound nanovesicles compared to conditioned culture medium extracellular vesicles

This study compares mesenchymal stem cell-derived matrix-bound nanovesicles (MBVs) with conditioned culture medium extracellular vesicles (liquid-EVs), identifying size, protein content, zeta potential, and tetraspanin profiles differences, and proposing specific markers for MBV identification.

De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics

This paper designs high-affinity GDF15 binders using AI-driven methods for cancer cachexia diagnostics and therapeutics, showing potent neutralization and biosensing capabilities.

Interpersonal physiological synchrony: estimation and clinical application to cardiac dynamics of parent-infant dyads

This paper introduces opMCI to measure physiological synchrony in parent-infant dyads and shows it increases after a shared reading intervention in preterm infants.

Input data when using neural networks to estimate lower-body torques from wearable sensors during gait: Is it of great influence?

This study examines how input data variations affect lower-body torque predictions using wearable sensors and neural networks, finding dataset quality more important than input variables.

3D-printing-assisted, microfabricated devices reveal hierarchical and temporal mechanosensing in high-density fibroblast culture

This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.