Discover, rate, and discuss biology preprints.

This paper develops a biophysical model to show glycocalyx can induce membrane tube formation through critical grafting density and polymer length, facilitated by actin forces and line tension.

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

This study shows that an IE3-derived scFV blocks fertilization by binding ZP2 and determines the structural basis of this interaction, offering insights for non-hormonal immunocontraceptives.

The paper identifies a stimulant derivative binding in a cryptic vestibular pocket of the 5-HT3A receptor using computational and experimental methods.

This study uses AIS and Catch Report data with advanced processing to detect fishing activities, achieving 92-93.7% accuracy in classification.

The paper uses Monte Carlo simulations to analyze the dynamic energy landscapes of PROTAC ternary complexes, identifying stable conformations and supporting PROTAC optimization.

This study uses molecular dynamics simulations and machine learning to analyze how mutations affect Smlt1473's binding to substrates, identifying key residues involved in substrate interaction.

This paper investigates the kinetic mechanism of p53 condensation and amyloid aggregation, revealing a pathway from coacervates to fibrils and suggesting therapeutic targets for p53-related cancers.

The paper shows that EB3 comet length at microtubule ends is independent of GTP-cap size, revealing a new mechanism involving phase separation and hydrodynamic instability.

This study uses single-vesicle tracking to show α-synuclein oligomers form pores through a three-stage process influenced by membrane curvature, charge, lipids, and ligands.

This study evaluates OPTIR for biological imaging, showing multifrequency imaging matches hyperspectral imaging speed and demonstrating IR probe utility across cell lines and organisms.

This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.

This study investigates how ApoA-I interacts with lipid membranes to induce shape remodeling and lipid phase separation in GUVs, revealing key steps in lipoprotein assembly.

This study investigates how crRNA binding induces structural changes in Cas7-11, revealing its conformational dynamics and how these changes regulate its function.

This paper engineers asymmetric lipid vesicles that enhance mRNA and protein delivery to cells, showing increased transfection efficiency and broad cargo compatibility.

This paper investigates how Roquin's two ROQ domains interact with different regions of the Ox40 mRNA 3UTR, revealing opposing effects on RNA structure stability and mRNA decay.

The paper develops a framework combining polymer physics and machine learning to estimate chromatin structures from Hi-C data with high accuracy.

This study shows that tension in the neck linker of kinesin-1 suppresses premature binding of the detached head, explaining coordinated stepping through allosteric regulation.

This study uses atomistic simulations to show that RNA structure is destabilized in biomolecular condensates due to interactions with peptides, with amino acid composition affecting RNA conformation.