Discover, rate, and discuss biology preprints.

The paper investigates how cortical and cytoplasmic forces coordinate to achieve planar cleavage in ascidian embryos.

This study shows that cell size affects cryopreservation outcomes in amphibian embryonic cells, with optimal cryoprotectant conditions varying by cell size.

This study identifies a non-canonical Notch-Wnt interaction that maintains prosensory domain identity by regulating Sox2 and Lmx1a through NICD-mediated suppression of Wnt activity.

The paper examines gene expression in electroreceptor and mechanosensory organs of sturgeon, identifying shared and distinct molecular features of their ribbon synapses.

This study identifies placental transcriptome genes and modules mediating the effect of prenatal phthalate exposure on placental efficiency and fetal growth.

This paper describes a protocol for using RNA interference in planarian embryos to study gene function during regeneration.

This study shows that hoxba and hoxbb clusters are essential for positioning zebrafish pectoral fins by inducing tbx5a expression and maintaining retinoic acid responsiveness.

This study investigates the role of endothelial Rho kinase (ROCK1/2) in vascular integrity and angiogenesis, finding that their loss leads to vascular defects and lethality.

The paper shows calcium waves in Drosophila retinal support cells coordinate uniform tissue patterning through gap junction networks and size-dependent mechanical responses.

The paper shows endodermal cells use contact inhibition of locomotion (CIL) mediated by EphA2 and RhoA to disperse uniformly during zebrafish gastrulation.

The paper identifies a shared regulatory region between Wnt1 and Wnt10b that is induced by tissue injury and essential for muscle regeneration.

This study shows that XIST is required for XCI in human extraembryonic cells, which is essential for their survival and development.

This study profiles mouse migratory primordial germ cells and their niches to show position-specific differences in non-canonical Wnt and Nodal-Lefty signaling during migration.

This study shows that Eed is essential for craniofacial osteoblast differentiation and mesenchymal proliferation in neural crest cells, identified through mouse genetics, single-cell RNA sequencing, and epigenetic profiling.

The paper identifies six cis-regulatory elements controlling mdka expression in zebrafish telencephalic NSCs during development and regeneration, showing that their cooperation is necessary for full expression.

The paper identifies an AmotL2-Yap1 module that regulates vascular pruning by integrating flow and junctional mechanics in zebrafish.

This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.

This study shows that PDGFR signaling is essential for postnatal development of perivascular fibroblasts in the brain.

The paper shows Erk signaling waves in zebrafish scale regeneration induce inhibitor transcript waves and modulate osterix transcription, linking wave dynamics to tissue growth and maturation.

This study identifies conserved gene expression patterns across the life cycles of brown algae by comparing transcriptomes of gametophyte and sporophyte stages in multiple species.