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Conditions and properties of non-Mendelian transmission of recombinants in female meiosis

The paper investigates non-Mendelian transmission of recombinants in female meiosis, showing that chromatids with crossovers have a transmission advantage under nutrient stress in Drosophila.

Implication of a rare variant in OPA1 in Cardiac Pathophysiology: From Cristae Remodelling to Contractile Dysfunction

The paper identifies a rare OPA1 variant linked to dilated cardiomyopathy (DCM) through whole-exome sequencing and functional analysis, showing its impact on mitochondrial dynamics and cellular health.

Efficient Gibson Assembly of Ultra-Large cDNAs: Generation of Full-length Wild-Type and Mutated futsch transgenes in Drosophila

The paper describes an efficient Gibson Assembly method for cloning full-length Drosophila futsch cDNA and generating transgenes to study its function in neurons.

Evidence for a regulatory role of the evolutionarily conserved sequence complementarity between tRNAs

The paper shows that tRNAs can form complementary pairs, leading to sequestration of rare tRNAs and affecting bacterial growth and phage replication.

EDTP Loss of Function Impairs Longevity and Reproduction

This study shows that EDTP loss of function in Drosophila reduces reproduction and lifespan, with effects restricted to developmental and adult stages.

A large-effect locus on chromosome 4 underlies circadian feeding rhythmicity in pigs

This study identifies a QTL on chromosome 4 associated with circadian feeding rhythmicity in pigs, linking it to genes involved in feeding behavior and energy homeostasis.

Wolf microevolution in the melting pot: range expansion, population sympatry, dynamic mosaic admixture zone and asymmetric gene flow

The paper analyzes wolf population dynamics in Central Europe, identifying range shifts, sympatric zones, and asymmetric gene flow between populations.

Beyond Exons: Linking Noncoding Heritability and Polygenicity across Complex Human Traits and Disorders

The paper quantifies how heritability is distributed across genomic regions for different polygenicity levels in complex traits, showing exons contribute less and intergenic regions more in highly polygenic traits.

Cyclin C nuclear release and mitochondrial dysfunction define molecular signatures of MED13L Syndrome

The paper identifies mitochondrial dysfunction and cyclin C mislocalization as consistent features of MED13L syndrome, linking them to clinical severity and suggesting potential biomarkers.

The histone demethylase Kdm5 and the ARGONAUTE proteins Piwi and Aubergine regulate female abdominal pigmentation in Drosophila melanogaster

This study identifies Kdm5 and Piwi/Aubergine as regulators of female abdominal pigmentation in Drosophila by modulating histone marks and pigmentation gene expression during pupal stages.

The evolutionarily conserved EHMT1/G9a histone methyltransferase family regulates sleep maintenance through ROS homeostasis in insulin-producing cells

This study identifies EHMT1/G9a's role in sleep regulation through ROS homeostasis in insulin-producing cells, linking it to sleep disturbances in Kleefstra syndrome and common insomnia.

Optimizing CRISPR/Cas9 mutagenesis in Drosophila da neurons to avoid cytotoxicity

This study optimizes CRISPR/Cas9 mutagenesis in Drosophila da neurons by developing uCas9 transgenes that reduce cytotoxicity while maintaining gene editing efficiency.

Parallel evolution under constraint shapes echinocandin resistance in Candida auris

Across 681 matched isolates and 22,388 genomes, high-level micafungin resistance in Candida auris arises through recurrent FKS1 hotspot mutations amid strong purifying selection, and FKS2 appears dispensable.

Genetic diversity within and between polyploid sugarcane (Saccharum spp.) families obtained via caryopsis using microsatellite markers and multicategory model

The paper evaluates genetic diversity within and between sugarcane families using microsatellite markers and distances to account for polyploidy, finding most variation is within families.

Response to divergent selection on meiotic recombination in Saccharomyces cerevisiae

The paper uses experimental evolution in yeast to study how recombination rates change under divergent selection, finding increased and decreased rates in selected lineages.

Optimizing DNA extraction from environmentally degraded bone samples for molecular identification of cetacean species

This paper presents an optimized DNA extraction protocol for degraded cetacean bone samples, successfully amplifying mitochondrial DNA from 55.6% of samples for species identification.

Regulatory Mechanisms of Maternal Imprinting at the Dlk1-Dio3 Domain

The paper investigates regulatory mechanisms of maternal imprinting at the Dlk1-Dio3 domain, showing that loss of expression is more detrimental than gain and identifying active regulatory factors on the unmethylated maternal chromosome.

A patient-derived LMX1B variant causes tissue-specific manifestations of nail-patella syndrome in mice

This paper creates a mouse model with a patient-derived LMX1B variant, showing tissue-specific effects of nail-patella syndrome.

Cohesin promotes genomic stability by suppressing unequal sister chromatid exchange

This study shows cohesin suppresses unequal sister chromatid exchange by maintaining arm cohesion and limiting distal repeat interactions in yeast.

X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments

The paper investigates the role of CTCF and cohesin in X-inactivation escapee domains and finds that these domains are self-sustaining chromatin compartments independent of CTCF and cohesin.