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The paper identifies de novo RBBP5 variants in individuals with neurodevelopmental disorders and shows they cause loss of function through structural and Drosophila model analyses.

The paper identifies seven genes in Drosophila melanogaster that suppress p53-induced apoptosis through insertional mutagenesis using the DEP transposon.

The paper investigates how chromatin states influence coordinated allelic transcriptional bursting during iPSC reprogramming and finds that chromatin accessibility correlates with allelic coordination.

This study identifies a self-regulatory mechanism of the 6mA methyltransferase AMT1 in Tetrahymena thermophila, showing that AMT1 modulates its own transcription through 6mA methylation and affects cell fitness.

This study identifies Rtt107's role in preventing genome instability by interacting with Rad55 and Slx4, showing distinct functions in limiting crossover events and maintaining rDNA stability.

This study genotypes 80 Ladakh individuals to analyze genetic lineages, admixture, and adaptation, finding distinct East Asian and Indo-European affinities with signals of high-altitude and immunity adaptation.

This study tests two models for TAD boundary formation in flies and finds that boundary pairing, not loop extrusion, determines TAD endpoints.

This paper introduces edLMM, a method that detects low-effect genetic variants using moderate sample sizes, improving missing heritability estimation.

The paper investigates how loop topology in Drosophila TADs affects physical and regulatory landscapes by replacing boundaries and analyzing the resulting structural and functional changes.

The paper uses statistical models to analyze seafood fraud in Metro Vancouver, finding consistent trends with past studies and highlighting the need for better management.

The paper shows that Ser mistranslation activates the integrated stress response without requiring uncharged tRNAs, suggesting ribosome stalling and collision.

This study identifies skeletal abnormalities in chd7-/- zebrafish, linking col2a1a depletion to craniofacial and spinal bone development defects in CHARGE syndrome.

The paper identifies that Mucorales fungi use a sealing-only tRNA ligase, implying that targeting sealing activity could lead to broader-spectrum antifungals.

This study identifies TET2 and INO80 as key genes in kidney disease pathogenesis through GWAS, single-cell analysis, and mouse models, showing their role in DNA damage response and disease progression.

The paper develops MAGESTIC 3.0, a CRISPR-based system for genome-wide variant installation in yeast, revealing missense variants and multiple causal variants in quantitative trait loci across environmental conditions.

The paper investigates a gene drive targeting the wupA gene in Drosophila to skew sex ratios, finding it can reduce female progeny and is effective across multiple species.

This study assesses the genetic diversity of cryopreserved livestock collections using new metrics and proposes a framework for managing genetic diversity in populations.

The paper investigates the relationship between regulatory information density and evolutionary constraint in non-coding DNA of Drosophila, finding that dense regulatory regions contribute significantly to constraint.

The paper identifies medulla-specific gene expression patterns in adult human kidney tissues using multi-omic data and corrects misassignments in the GTEx database.