Discover, rate, and discuss biology preprints.

This study shows that exposure to P. aeruginosa in C. elegans reduces brood size by inducing programmed germ cell death and mitotic quiescence, which are reversible upon removal of the pathogen.

The paper shows genetic effect sizes are similar across African and European populations for most traits, suggesting shared causal mutations and improving GWAS portability.

This paper introduces ARTi, a method using synthetic shRNAs to achieve precise and controllable RNAi for gene suppression.

The paper models how SARS-CoV-2 mutations are transmitted within-host, finding that mutations affecting innate immune evasion have higher transmission probabilities than those affecting humoral evasion.

This paper introduces a cross-protein transfer learning framework that improves disease variant prediction using deep mutational scanning data from few proteins, achieving better specificity than existing models.

This study investigates the distinct roles of RAD-54.L and RAD-54.B in C. elegans meiotic prophase, showing RAD-54.L facilitates RAD-51 removal while RAD-54.B prevents excessive RAD-51 accumulation.

This paper introduces a method to rewrite large genomic regions using CRISPR/Cas9, enabling simultaneous editing of 7kb+ DNA sections without selection.

This study maps eQTLs in the striatum of Diversity Outbred mice and provides tools for querying genetic variants and co-expression networks related to striatal gene expression and addiction-related behaviors.

The paper analyzes scRNA-seq data from multiple mouse tissues to show imprinted genes are enriched in stem and endocrine cell types.

The paper identifies FLN-2 as a third pathway mediating P-cell nuclear migration in C. elegans, functioning alongside LINC complexes and CDC-42/actin pathways to maintain nuclear envelope integrity during migration through constricted spaces.

The paper uses human genetics and CRISPR/Cas9 to recreate a naturally occurring mutation that increases red blood cell production and shows its combination with a beta-thalassemia correction strategy enhances RBC development.

The paper identifies LQGH1, a glycosidase in Bombyx mori that mediates quercetin uptake by deglycosylating quercetin glycosides, and shows its conservation and role in silk production.

The paper compares transcriptomes of excitatory neurons from Alzheimer's patients and controls, identifying 621 differentially expressed genes and linking them to known Alzheimer's genes and functional networks.

The paper examines genetic dependence features of genes and their role in determining pathogenicity and clinical features of genetic diseases.

The paper shows that yeast cells with impaired early anaphase Cdc14 release can complete meiosis without ribosomal DNA disjunction in meiosis I, suggesting this process is not essential for meiosis.

This study investigates the genetic structure and genome-wide associations of Kazakh horses, identifying SNPs linked to traits like size and weight.

This paper identifies Bmmamo as the gene responsible for the dilute black (bd) phenotype in silkworms, linking it to female sterility and larval pigmentation.

The paper investigates bypass activity in Drosophila Abd-B regulatory boundaries, finding that bypass elements must be in the domain driving Abd-B expression and that bypass activity is location-dependent.

This study presents transcriptomic and proteomic analyses of obesity and T2D in cynomolgus monkeys, identifying tissue-specific molecular changes and potential therapeutic targets.