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The paper develops a method to infer autoregulation in gene expression using variance-to-mean ratios and applies it to experimental data to identify potential autoregulated genes.

The paper identifies 15 genomic loci influencing proteasome activity in yeast using single-cell measurements and CRISPR-based engineering, revealing substrate-specific genetic effects.

The paper evaluates all possible CXXX sequences as farnesyltransferase targets in yeast using a reporter system, revealing expanded specificity beyond the canonical CaaX motif.

The paper shows that CAG/CTG repeats in ssDNA gaps influence repair kinetics, leading to repeat expansions or contractions and chromosome breaks.

The paper maps de novo telomere addition hotspots in yeast using a high-throughput method and computational analysis, showing enrichment in subtelomeres and Cdc13 binding.

This study identifies genetic adaptations in Nothofagus pumilio to climate factors like temperature and day length across its range using landscape genomic methods.

The paper introduces BIGA, a cloud platform for analyzing cross-trait genetic architecture using GWAS summary statistics, enabling unified data analysis and resource sharing.

This paper estimates SNP-based heritability of Alzheimer's disease across five cohorts, showing it ranges from 38-66%, with microglia genes explaining most of the heritability.

This paper evaluates the impact of participation bias in the UK Biobank by applying inverse probability weighting to genome-wide association analyses, revealing significant distortions in genetic correlations and Mendelian Randomization estimates.

This study maps human glucokinase variant activity using a yeast complementation assay, identifying activity patterns linked to disease and providing insights for variant interpretation and therapeutic development.

This study compares meiotic DSB and synapsis dynamics in American and Australian marsupials, revealing evolutionary shifts in meiotic programs.

This paper describes a machine vision guided robot that automates microinjection in fruit fly and zebrafish embryos, achieving high throughput and comparable proficiency to human experts.

The paper analyzes rare functional variation in genes related to ethanol metabolism in severe alcohol dependence cases using a case-only design and WES data from the island of Ireland.

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

This study identifies NHR-49 as a regulator of stress resilience and proteostasis in C. elegans, linking lipid homeostasis to proteotoxic stress responses.

The paper shows that a PTEN p.I135L mutation and an ASD genetic background together disrupt cortical neurogenesis in iPSC-derived NPCs and organoids.

This study uses multi-omics data from grass hybrids to identify gene and metabolite networks associated with agronomic traits, finding conserved hubs but limited predictive power of network features.

This study uses multi-locus genotype identity scans on ancient DNA to detect natural selection in Holocene Europe, identifying new selection signals not found by single SNP approaches.