Discover, rate, and discuss biology preprints.

This paper develops a combinatorial mRNA therapy for arthritis that inhibits inflammation and promotes cartilage regeneration, showing efficacy in pre-clinical models.

This study shows that Echinococcus granulosus antigen B binds LPS and prevents TLR4 activation in dendritic cells, inhibiting proinflammatory responses.

This study integrates single-cell transcriptomic data with genetic profiles to identify critical cell types and genes in inflammatory bowel disease.

The paper identifies two distinct regulatory T cell subsets in colorectal cancer with opposing roles in tumor growth and prognosis.

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

This study shows that combining NKTR-255 with CAR-T therapy enhances tumor control by boosting CAR-T function and endogenous anti-tumor immunity in solid tumors.

This study shows that IL-36γ signaling reduces the anti-inflammatory M2a macrophage state by decreasing CD163 and lipid uptake receptors, while increasing M1 markers and cytokines.

This study identifies a noncanonical PRDM1+ Tfh subset selectively depleted in HIV viremia but recoverable under ART, highlighting its susceptibility to infection and implications for HIV reservoirs.

This study demonstrates a method to generate antigen-presenting vesicles displaying pMHCI using engineered constructs, which selectively stimulate T cells for potential cell-free immunotherapy.

This study shows that GDF3 promotes inflammation in aged adipose tissue macrophages via SMAD2/3 signaling and chromatin changes, offering a therapeutic target for age-related inflammation.

The paper uses single cell proteomic analysis to identify distinct functional states of neutrophils in human glioblastoma, revealing clusters with pathogenic and anti-tumorigenic properties not detectable by scRNA-seq.

This study generates pro-regenerative macrophages from hESCs to treat OA, showing they reduce inflammation and restore cartilage via TNFAIP3 signaling.

This study identifies disrupted lymphocyte chemotaxis in idiopathic multicentric Castleman disease, linking dysregulated chemokine production to germinal center dysfunction and lymphadenopathy.

LoFT-TCR improves TCR-antigen binding prediction using LoRA fine-tuning of ESM-2, achieving better accuracy than existing methods.

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

This study uses molecular dynamics simulations to show that CDRs significantly influence antibody framework dynamics through CDR-FW correlation networks, highlighting their impact on structure and function.

This study shows that genetic differences in mice lead to distinct myelopoiesis and macrophage polarization outcomes during Chlamydia trachomatis infection, affecting whether the infection becomes chronic.

The paper identifies GNG4 as a marker for activated CD4 T follicular helper cells in human germinal centers using multimodal single-cell analysis.

This study identifies dysfunctional type 1 immunity in SSc patients through altered T cell subsets and reduced IFN-γ production.