Discover, rate, and discuss biology preprints.

This study identifies colonic metabolic and microbial changes in a mouse model of metabolic syndrome, showing similarities to human data and suggesting the colon as a potential therapeutic target.

This study shows that reducing S-nitrosylation of Cx43 in DMD mice prevents arrhythmias and myocardial injury under cardiac stress.

This study investigates how the CRF system in rainbow trout spleen responds to inflammation, showing differential regulation of CRFR1 and CRFR2 by cortisol and NF-κB.

This study uses dual lineage tracing to show irradiation reduces SMC investment in atherosclerotic lesions and increases EC-derived cells, leading to reduced plaque stability.

This study shows that fixed-dose streptozotocin in HFD-fed mice induces a stable T2D-like phenotype, contrasting with weight-adjusted dosing which causes variability.

The paper analyzes daily gene expression rhythms in the regenerating colon using single-cell transcriptomics, revealing cell-type specific patterns and identifying a resource for future studies.

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

This study examines how lifestyle changes in Indigenous Orang Asli communities in Malaysia affect sleep patterns and circadian rhythms, finding delayed timing and shorter duration with improved quality.

This study develops glomerulus-targeted nanotherapy using collagen IV-α3 binding peptides to improve renal function and reduce inflammation in lupus nephritis.

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

This study shows that reducing MLKL in mice prevents diet-induced obesity and improves insulin signaling in fat cells.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This study identifies miR-100-5p as a regulator of postprandial triglyceride response by targeting PCSK9, suggesting its potential as a biomarker for cardiovascular risk.

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

This study identifies DI-1859, a selective Cul3 neddylation inhibitor, that reduces hyperglycemia by enhancing insulin sensitivity and secretion in mice.

This study identifies SLC25A34 as a fasting-inducible mitochondrial carrier that mediates PEP import, linking amino acid catabolism to muscle preservation during fasting.

This study shows that secretin receptor knockout mice have impaired renal base excretion and increased base retention during prolonged base-loading.

The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.

This study investigates the acute effects of intra-articular IDO-1 liposomes after ACL injury, showing reduced tryptophan, inflammation markers, and altered T cell ratios, with increased cartilage thickness in rats.