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The paper presents the cryo-EM structure of Legionella pneumophila's MCC and identifies substrate-induced filamentation, suggesting a role in bacterial life cycle differentiation.

The paper identifies HSF1-mediated proteostasis decline as a link between aging and sleep disruption through multi-omics analysis across human and mouse tissues.

This study shows E2F3 amplification in bladder cancer cells leads to premature mitosis, which can be targeted by G2/M checkpoint inhibitors.

This paper develops a detailed, data-driven biophysical model of hippocampal CA1 pyramidal neurons that captures diverse electrophysiological features and validates its accuracy through experimental comparison.

This study identifies how a MDA5 mutation disrupts ATPase activity, leading to aberrant interferon signaling and autoimmunity.

This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.

This paper proposes a model showing how spatial navigation architectures can construct universal cognitive maps for abstract reasoning tasks like analogy making and perspective taking.

This study shows autoattractants enhance immune cell migration but can also cause aggregation, with optimal communication balancing cell coordination and movement efficiency.

This paper designs synthetic proteins that inhibit TLR4 signaling by binding its transmembrane domain, demonstrating the importance of transmembrane interactions in immune signaling.

This study shows that uropathogenic E. coli biofilms exhibit evolutionary stratification, with gene expression becoming younger and more divergent as biofilms develop.

Songbird is a single cell whole genome sequencing copy number caller that detects whole genome duplication and outperforms existing tools in breakpoints identification and true copy number detection.

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

The paper uses Hi-D to track chromatin motion in live human cells and finds that DNA content doubling, not cohesin, reduces chromatin mobility during the cell cycle.

Fishash assigns perturbations to cells in Perturb-seq data using Fisher's Exact Test, improving accuracy and speed over existing methods.

The paper shows that sociosexual interactions in fruit flies can shift their daily activity patterns, enabling coexistence by altering temporal niches.

This paper identifies SepIVA as a divisome activator in M. smegmatis, showing it is inhibited during DNA damage by disrupting its interaction with FtsQ.

This study determines the cryo-EM structure of HIV-1 capsid lattice with lenacapavir, showing how it disrupts capsid formation and function during virion maturation.

This study identifies a complex inositol phosphate network in the streptophyte alga Chara braunii, showing its structural and environmental responsiveness before land plants evolved.

The paper identifies ZNF121 as a cofactor that enhances YTHDF2-mediated mRNA decay by facilitating its binding to target transcripts, thereby modulating mRNA stability and cell-cycle regulation.