Discover, rate, and verify biology preprints.

Bacterial major vault protein homologs form divergent vault structures

The paper identifies bacterial MVP homologs and reports cryoEM structures of vaults from Corallococcus praedator and a Deltaproteobacteria bacterium, revealing novel symmetries.

Age-dependent mechanical stress underlies unexpected vestibular differentiation and regeneration patterns

This study shows that mechanical stress influences age-related changes in vestibular hair cell differentiation and regeneration through Notch signaling.

A PTN-Rich MSC Subtype Promotes Cartilage Repair in End-Stage Knee Osteoarthritis

The paper identifies a PTN-rich MSC subtype that enhances cartilage repair in KOA by modulating key inflammatory and repair pathways.

Leave-One-Out-Cross-Validation Based Machine Learning Algorithms for Efficient, Scalable, and Robust Prediction of Artemisinin Resistance in Plasmodium falciparum Kelch13 mutants.

The paper develops machine learning models to predict artemisinin resistance in Plasmodium falciparum K13 mutants using physicochemical and structural features of mutations.

Electrophysiological Dynamics of Default Network Suppression

The paper investigates network competition in the brain using electrophysiology and neuroimaging, finding temporally layered antagonism between default and task-related networks, with distinct patterns in the hippocampus.

SAMP1/TMEM201 protects alveolar type 2 cells from DNA damage-associated senescence and restrains pulmonary fibrosis

This study identifies SAMP1 as a protector of alveolar type 2 cells against DNA damage-induced senescence and shows its role in limiting pulmonary fibrosis in a mouse model.

Homology-aware average nucleotide identity estimation at scale with TurboANI

TurboANI is a fast, homology-aware ANI estimator with up to ~40,000x speedup over alignment-based methods and better accuracy than FastANI and skani.

Environmental Frass Remodels the Larval Gut Microbiome to Enable Black Soldier Fly (Hermetia illucens) Bioconversion of Livestock Manure

This study shows that wild frass enhances BSFL growth on rabbit manure by introducing lignocellulose-degrading microbes, which are lost in captive-reared frass.

π-SPECFormer: A Mass Spectrometry-based Foundation Model for Decoding the Dark Proteome

This paper introduces π-SPECFormer, a foundation model for mass spectrometry-based proteomics that decodes the dark proteome by pre-training on unannotated spectra and outperforms baselines in peptide sequencing and modification detection.

Synthetic chromatin engineering for STAT1 reactivation toward restoring cisplatin sensitivity in breast cancer

This study reactivates STAT1 in cisplatin-resistant breast cancer using synthetic chromatin engineering, restoring cisplatin sensitivity through enhanced nuclear translocation and transcriptional activation.

Programmable interphyla communication for Staphylococcus aureus by transferability of homoserine lactone sensors between Bacillales bacteria

This study demonstrates the transferability of homoserine lactone sensors between Bacillales bacteria, enabling programmable interphyla communication between Gram-negative and Gram-positive species.

Mitochondrial Dysfunction is Part of a Novel Mechanism for Chemotherapy-Induced Neuropathic Pain

This study identifies persistent spinal mitochondrial dysfunction and increased mPTP susceptibility as features of chemotherapy-induced neuropathic pain and supports mitochondrial protection as a therapeutic strategy.

A caudate-centered network for alexithymia derived from patients with brain tumors

The paper identifies a caudate-centered neural network associated with alexithymia using lesion network mapping in a glioma patient cohort.

Uniformly re-analysed public omics data and graded meta-analyses of exercise responses in humans and rodents

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

Dynamic mechanical sorting biases niche occupancy and lineage outcome during development of bilayered glandular epithelia

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

Hypoxic Stress Induces LARP1-Driven Stress Granules That Protect mRNAs from Decay to Sustain Mitotic Cell Cycle Progression

This study shows hypoxia induces LARP1-driven stress granules that protect mRNAs from decay, sustaining mitotic progression in cancer cells.

Identifying a neurochemical signature of the paraventricular nucleus of the thalamus that predicts individual variability in cue-reward learning

The paper identifies a neurochemical signature in the paraventricular nucleus of the thalamus that predicts individual differences in cue-reward learning in rats.

Developmentally-regulated splice remodeling shapes functional CACNA1C channel diversity during human neurodevelopment

This study identifies developmentally-regulated alternative splicing of CACNA1C during human neurodevelopment and shows it affects CaV1.2 channel function.

PROST: An Open Toolbox, Harmonised Multi-Lab Dataset, and Meta-Analysis of Ankle-Foot Roll-Over Shape

This paper develops a harmonized multi-lab dataset and analysis tool for ankle-foot roll-over shape, finding that ROS geometry is participant-specific and not predicted by anthropometrics.

GeneEmbedLLM: Harnessing Large Language Models for Gene Functional Embedding and Association Prediction

This paper introduces GeneEmbedLLM, a framework using large language models to generate gene embeddings from multi-source textual annotations, achieving competitive performance in various downstream tasks.