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Assessing Zymoseptoria tritici Candidate Effectors in the Non-Host Nicotiana benthamiana Reveals Immune Recognition and Potential Host-Independent Activities

The paper assesses Zymoseptoria tritici candidate effectors in Nicotiana benthamiana to identify immune recognition and potential host-independent activities, finding that expression timing and signal peptides influence effector phenotypes.

Genomic insights into the human gut commensal Megasphaera elsdenii: Relatedness and metabolic potential compared to animal isolates

This study compares Megasphaera elsdenii genomes from human and animal gut isolates, finding they are genetically similar and share metabolic functions, with no host-specific clustering or virulence genes.

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

In-Chip Volumetric Printing of Collagen-I Scaffolds for Perfusable and Stretchable Mammary Tissue Models

This paper develops a method to print collagen-I scaffolds directly inside organ-on-chip devices, enabling perfusable and stretchable mammary tissue models with compartmentalized fluidic control.

An Open-Source, Excitation-Resolved UV-NIR Imaging Platform for Bioluminescence, Luminescence-Decay, and Chemical Discrimination Measurements

AURORA-MSI is an open-source multispectral imaging platform that enables excitation-resolved measurements of bioluminescence, luminescence decay, and chemical discrimination without photon-counting instrumentation.

A Meta-Analysis of 515 Human Proteomes Defines the Core Composition and Contaminants of Plasma Extracellular Vesicles isolates

This study defines the core proteome and contaminants of plasma extracellular vesicles through a meta-analysis of 515 human proteomes, revealing distinct biological sources and functional modules.

Mouse suppressyn-like 1 suppresses membrane fusion through envelope glycoprotein recognition

This paper identifies mSUPYNL1 as a retrovirus-derived protein that suppresses membrane fusion through direct recognition of envelope glycoproteins, distinct from receptor interference mechanisms.

General prediction of T cell receptor antigen specificity from sequence using AlphaFold 3

This paper uses AlphaFold 3 to predict T cell receptor antigen specificity from sequence, achieving high accuracy on unseen epitopes.

Electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive

The paper investigates the electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive and finds they exhibit distinct firing patterns and response characteristics compared to non-projecting neurons.

Drivers of mosquito presence and abundance in urban and garden ponds in a European city

The paper investigates mosquito presence and abundance in urban and garden ponds, finding that fish presence negatively affects mosquitoes, while urbanization has a minor role.

The first comprehensive case study of early-emerging prosopometamorphopsia

This paper presents the first comprehensive case study of early-emerging prosopometamorphopsia, detailing its clinical manifestations and neural correlates.

Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress

This study identifies a mechano-adaptive response in the colonic epithelium to mechanical stress, showing that myosin II and calcium influx coordinate junctional reinforcement to preserve barrier integrity.

Knowledge, Attitudes and Practices on Antimicrobial Resistance Among Practising Veterinary and Para-veterinary Professionals in Zambia

This study assesses knowledge, attitudes, and practices of veterinary and para-veterinary professionals in Zambia regarding antimicrobial resistance, finding strong awareness but persistent risky practices due to structural barriers.

YBX3 overexpression in mesothelioma drives aberrant cell proliferation

This study identifies YBX3 as an oncoprotein in mesothelioma that drives cell proliferation through SLC7A5/LAT1-mediated amino acid uptake and shows JPH203 as a potential therapeutic agent.

A Deep Quantitative Proteome Turnover Platform for Human iPSC-derived Neurons

The paper develops a platform to measure protein turnover in human iPSC-derived neurons, revealing conserved and subtype-specific proteome dynamics.

Intrinsic Cellular Persistent Firing Sustains Hippocampal Spatial Representations during Working Memory

The paper shows that hippocampal place cells maintain spatial information through intrinsic persistent firing via TRPC4 channels during working memory tasks in mice.

Shared Pain, Shared Decisions: How Empathy Shapes Social Conformity Through Physiology and Visual Attention

This study investigates how empathy influences social conformity through physiological arousal, visual attention, and socio-emotional traits using a combination of behavioral and physiological measures.

A nematic framework for sprouting angiogenesis

This study uses a nematic framework to show that endothelial cell orientation gradients drive angiogenic sprouting, with implications for therapeutic strategies.

Astroglial Dysfunction in Models of CDKL5 Deficiency Disorder

This study generates novel human models of CDKL5 Deficiency Disorder and identifies astrocytic dysfunction in these models.

Sex- and Age-Specific Development of ssRNA Virus Receptor Expression in the Human Brain

This study identifies sex- and age-specific developmental patterns of ssRNA virus receptor expression in the human brain using postmortem transcriptomic data.