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Peripheral Exercise Transcriptomes Do Not Converge on Glutamatergic or Neuroinflammatory Signatures: A Cross-Platform Meta-Analysis

This study analyzes peripheral transcriptomic responses to exercise and finds no convergence on glutamatergic or neuroinflammatory signatures across tissues.

Quantifying heritability in functional regions of the coding and non-coding genome across diverse individuals

The paper estimates whole-genome heritability of complex traits across diverse populations, finding rare and non-coding variants significantly contribute to heritability.

Ultrasensitive detection of neuronal DNA using genome-wide non-CG methylation patterns

This paper detects neuronal DNA in cfDNA using non-CpG methylation patterns, finding elevated levels in neurological conditions and brain-dead donors.

The genetic architecture of human DNA methylome variation

This study develops pangenome-based frameworks to analyze DNA methylome variation across diverse human genomes, identifying genetic factors influencing methylation patterns and their associations with complex traits.

Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons

This study shows that elevated α-synuclein increases basal mitophagy in Parkinson's dopamine neurons, leading to mitochondrial dysfunction and neuronal activity deficits, which can be reversed by DRP1 inhibition.

Foreign Body Responses Adapt to Systemic Immunosuppression to Maintain Local Immune Homeostasis Through Decorin-Associated Signaling

Nanobodies against Plasmodium vivax AMA1 block parasite invasion

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

Incorporating tandem repeats improves gene expression prediction models

This study improves gene expression prediction models by incorporating tandem repeats, showing significant performance gains and identifying nonlinear effects on gene expression.

Mitotic centromeres organize in repeat-subunits with specialized histone landscape and multi-domain architecture as revealed by expansion microscopy

The paper uses expansion microscopy to reveal the repeat-subunit organization and multi-domain architecture of human mitotic centromeres, including specialized histone modifications.

When touch leads vision: flexible sensory leadership during active texture exploration

The paper investigates how vision and touch coordinate during texture exploration, finding that touch can lead vision when texture information is critical, but vision takes the lead when visual cues are more informative.

A Unique Promoter Architecture Defines Menin-KMT2A Complex Selectivity

The paper identifies a unique promoter architecture that defines Menin-KMT2A complex selectivity and its association with gene regulation and leukemia.

Development of the Highly Sensitive Horse questionnaire to assess horses' sensory processing sensitivity

The paper develops and validates a questionnaire to assess sensory processing sensitivity in horses, identifying two key dimensions and demonstrating its reliability and unique explanatory power for behavior.

Cellular context shapes the transcriptomic impact of somatic variants

The paper shows that somatic variants' transcriptomic impact depends on cellular context, not just sequence, using single-cell transcriptomics and new tools.

Effect of Varying Cigarette Smoke Concentrations and Durations on the Retinal Pigment Epithelium

This study examines how different concentrations and durations of cigarette smoke condensate exposure affect oxidative stress, autophagy, EMT, and cell death in human and mouse RPE cells.

Identification of cis-Acting Elements that Regulate Influenza A Virus Segment 7 Differential mRNA Splicing

This study identifies cis-acting elements that regulate splicing balance between influenza A virus segment 7 mRNA1 and mRNA2, revealing key sequences that influence M1 and M2 protein expression.

Multiple domains of Mata1 transcription factor contribute to binding site specificity

The paper identifies that multiple regions of the Mat1 transcription factor contribute to DNA-binding specificity across species.

Leakage-Controlled Benchmarking of Variant Effect Predictors and Development of Gradient-Boosting Consensus Model

The paper benchmarks variant effect predictors using a leakage-controlled dataset and develops a gradient-boosting consensus model that outperforms existing tools.

Prolactin Receptor Long Isoform ΔS1 Expression is Reduced in the Dorsal Root Ganglia of Humans with Chronic Pain

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

Why development time matters: temperature influences plasticity while nutritional stress reshapes selection and evolutionary potential

This study shows that temperature has the largest plastic effect on development time in Drosophila, but nutritional stress more strongly influences selection and evolvability.

Recognition of the centromere-binding protein Ndc10 by Scm3HJURP directs Cse4CENP-A deposition at native centromeres

The paper shows Scm3HJURP facilitates Cse4CENP-A deposition at native centromeres by interacting with Ndc10, enhancing Cse4 assembly efficiency in yeast.