A. C. Huttenlocher

The paper identifies a novel epithelial cell type in zebrafish fins, spike cells, and shows their role in maintaining immune cell niche homeostasis through interactions with mpeg1+ immune cells.

This paper identifies SppA as a critical protein for septal integrity in A. fumigatus, showing its role in antifungal tolerance and virulence.

Vimentin-driven maturation of col1a1a-positive fibroblasts after larval zebrafish burn parallels fin development, but prolonged neutrophil presence delays fibroblast maturation and organized collagen regrowth.

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

This paper identifies population-specific transcriptomic shifts in Aspergillus species, showing how transcriptomic reorganization drives secondary metabolic diversification and domestication in A. oryzae.

This paper establishes an ex vivo porcine skin model to study antiseptic effects on microbial communities and lipids, finding chlorhexidine gluconate reduces culturable microbes but increases Gram-negative taxa.

This study uses optical metabolic imaging to show neutrophils rapidly shift to a reduced redox state upon activation, with heterogeneous responses across cells and donors.

This study shows that GPR132b in zebrafish affects wound healing and infection resistance by modulating macrophage activity and lipid signaling pathways.

This study shows that mature neutrophils can rapidly reactivate mitochondrial metabolism in response to stimuli, impacting their function and suggesting therapeutic potential for mitochondrial pyruvate carrier inhibitors.

This study shows that chlorhexidine gluconate reduces viable skin microbial bioburden but does not achieve complete sterility, and temporarily increases pathogen abundance before microbiome recovery.

This paper establishes a zebrafish burn wound model to study fungal colonization and host immune responses, finding that macrophages and neutrophils control fungal infection with some redundancy.

The paper identifies a new external immune organ in zebrafish, the axillary lymphoid organ, suitable for live imaging of immune cell dynamics.

The paper uses live imaging in zebrafish to show T cells adapt their migration strategies based on tissue-specific geometries, using different actin structures in different environments.

This study shows that GATA1-deficient iPSC-derived neutrophils have enhanced antifungal activity against Aspergillus fumigatus, mediated by CD18 integrin.

The paper discovers co-zorbs, motile multispecies biofilms formed by Flavobacterium johnsoniae that transport other bacteria, revealing a new type of bacterial movement and cooperation.

The paper shows isotonic medium treatment reduces epithelial damage spread and microbial colonization in burn wounds in larval zebrafish and human skin.

This study uses real-time imaging in zebrafish to show that macrophage protrusive motility, regulated by Rac2, influences melanoma invasion.

This study shows that S. aureus supernatant increases melanoma invasion in zebrafish, likely mediated by bacterial lipids.

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

This study shows that ARPC1B in both neutrophils and endothelial cells regulates neutrophil motility, with endothelial ARPC1B being sufficient to drive neutrophil behavior.

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

This study shows that a high-cholesterol diet changes macrophage polarization and worsens liver inflammation and cancer progression in zebrafish with NAFLD/NASH-related HCC.