B. Zhou

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

This paper investigates how SARS-CoV-2 Envelope and Membrane proteins modulate Spike protein maturation and retention, showing their role in optimal VLP formation with Nucleoprotein.

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

This paper introduces a framework to study behavioral evolution by estimating ancestral behavioral repertoires using computational methods and behavioral data from fruit flies.

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

This study identifies high mannose as a key mediator of influenza severity through glycomic analysis in a ferret model.

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

The paper analyzes CD45 isoforms in T cells from liver cancer patients to show their role in T cell heterogeneity and function.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

The paper maps the molecular diversity of lymph node blood vascular endothelial cells at single-cell resolution, identifying novel subsets and their roles in immune cell recruitment and vascular homeostasis.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study found that a significant proportion of E. coli isolates from ready-to-eat lettuce in Northern California carry beta-lactam resistance genes, posing a potential risk for human infections.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

This study uses single-cell RNA sequencing to analyze viral transcription and host responses in influenza-infected cells, revealing cell-to-cell variation driven by defective viral genomes.

The paper examines how influenza virus type and vaccination status influence nasopharyngeal microbiota composition in infected individuals and healthy controls.

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.

This study identifies deregulated protein complexes in prostate cancer tissues using quantitative proteomics and reveals differences between low-grade and high-grade prostate cancer.

The paper analyzes crop breeding networks for cassava, potato, rice, and wheat to evaluate their structure and resilience in deploying resistance genes against diseases.

The paper develops a non-Gaussian Bayesian theory of vocal learning in songbirds that explains behavioral observations through distributional learning and confirms predictions with experimental data.

This study identifies genomic variations in normal lung tissues paired with lung adenocarcinomas, revealing tobacco-induced DNA damage and associations with patient prognosis.