C. Li

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This study investigates the genetic and physical interactions between SQUAMOSA and SVP MADS-box proteins in wheat spike development, showing their roles in regulating meristem transitions and floral development.

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

This study identifies an alternative P2 symmetry in chemoreceptor arrays of Treponema denticola, adapted to high membrane curvature, revealing new structural features and functional roles of CheA and CheW-CheR-like proteins.

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study shows that enrofloxacin treatment in neonatal chickens alters intestinal microbiota and metabolome, leading to prolonged Salmonella Typhimurium infection and hindered recovery.

This study shows that intermittent anti-PI3K treatment can overcome immune checkpoint therapy resistance in Pten-null prostate cancer by converting 'cold' tumors into T cell-inflamed ones.

The paper identifies 997 MYB genes in wheat, focusing on 445 R2R3-MYBs, and analyzes their expression patterns across 61 tissues and time points, revealing subgroup conservation and duplication mechanisms.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

This study characterizes the 24-nt siRNA landscape in rice zygotes, revealing a redistribution towards the vegetative profile and epigenetic resetting before the first embryonic division.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study investigates how anionic amino acids in Dispersin B affect PNAG substrate recognition and hydrolysis, showing that D147 enhances catalytic activity with cationic PNAG.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study identifies gene expression changes and pathways involved in passion fruit ripening and senescence using RNA sequencing and validates findings with RT-qPCR.

This study uses multiscale simulations to show that SERCA facilitates passive proton transport through a transient water pore on the microsecond timescale.

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

The paper characterizes antibiotic resistance genes and opportunistic pathogens in a hospital environment using genomic sequencing and identifies multidrug-resistant strains persisting for over 8 years.