Author

W. Hong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Immunology· 2 Animal Behavior & Cognition· 1 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

C. Li· 2 shared C. Zhang· 2 shared L. Liu· 2 shared M. Wang· 2 shared Y. He· 2 shared Z. Xu· 2 shared A. Li· 1 shared A. Mirazimi· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

C. Li

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

Y. Chen, Q. Jiang, q. yang, C. Zhang, C. Hou, w. hong, m. du, X. Shan, x. li, D. Zhou, d. wen, y. xiong, K. Yang, Z. Lin, j. song, , J. Wang

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

bioRxiv · Jan 25, 2024Pathology

Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association

H.-M. Wu, N.-J. Huang, Y. V. Yang, L.-P. Fan, T.-Y. Tang, L. Liu, Y. Xu, D.-T. Liu, Z.-X. Cai, X.-Y. Ren, Z.-H. Yao, J.-Z. Chen, X. Huang, C. Zhang, X. You, , S.-Y. Lin

This study shows probucol reduces high-fat diet-induced cognitive and social impairments in mice without affecting obesity or metabolic homeostasis, by disrupting redox-inflammation links.

bioRxiv · Sep 5, 2023Animal Behavior & Cognition

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

T. Ma, X. Liu, H. Su, Y. He, F. Wu, C. Gao, K. Li, Z. Liang, D. Zhang, X. Zhang, K. Hu, S. Li, L. Wang, M. Wang, S. Yue, , Y. Fan

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

bioRxiv · Nov 15, 2022 · PreprintBiophysics

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

G. Liao, x.-x. Fan, H. Lau, Z. Liu, C. Li, Z. Xu, Y. Zhang, X. Qi, D. Li, Q. Zhu, L. Chen, H. ZHOU, S. Zhu, B. Ke, H. Pan, , l. liu

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

bioRxiv · Aug 23, 2021 · PreprintImmunology

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by sequential intermittent anti-PI3Ka/b/δ and anti-PD-1 treatment

Z. Qi, W. Hong, Z. Xu, l. zhang, Y. Zou, W. Yan, C. Li, N. Liu

This study shows that intermittent anti-PI3K treatment can overcome immune checkpoint therapy resistance in Pten-null prostate cancer by converting 'cold' tumors into T cell-inflamed ones.

bioRxiv · Oct 17, 2020 · PreprintCancer Biology

BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.

X. Hua, Q. Liang, M. Deng, J. He, M. Wang, W. Hong, J. Wu, B. Lu, S. Leptihn, Y. Yu, H. Chen

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

bioRxiv · Sep 5, 2020Microbiology

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Z. Deng, J. Zhen, G. F. Harrison, G. Zhang, R. Chen, G. Sun, Q. Yu, N. Nemat-Gorgani, L. A. Guethlein, L. He, M. Tang, X. Gao, S. Cai, J. A. Shortt, C. R. Gignoux, , P. J. Norman

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

bioRxiv · Jul 29, 2020Immunology

Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2

Z. Zheng, V. M. Monteil, S. Maurer-Stroh, C. W. Yew, C. Leong, N. K. Mohd-Ismail, S. C. Arularasu, V. T. K. Chow, R. T. P. Lin, A. Mirazimi, W. Hong, Y.-J. Tan

This study shows that monoclonal antibodies against SARS-CoV's S2 subunit cross-react with SARS-CoV-2, highlighting sequence conservation and potential utility in diagnostics.

Eurosurveillance · Jul 16, 2020Peer-reviewedMicrobiology

Rapid Determination of Antibiotic Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolism

W. Hong, J.-X. Cheng

This paper demonstrates a rapid method for antibiotic susceptibility testing using stimulated Raman scattering imaging of D2O metabolism in bacteria.

bioRxiv · Dec 14, 2018 · PreprintMicrobiology

JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke

W. Geng, H. Tang, Q. Dai, W. Hong, K. Han, D. Jia, Y. Mo, Y. Lv, H. Fu, J. Zheng

This study shows JNK-IN-8 improves functional recovery in ischemic stroke by reducing neuroinflammation through the JNK/NF-κB pathway.

bioRxiv · Oct 21, 2018Cancer Biology