C. Zhang

This study investigates how variations in P450 oxidoreductase (POR) affect the aromatase activity of CYP19A1 polymorphisms R264C and R264H, showing differential impacts based on POR variants.

This study identifies a viral anti-CRISPR enzyme that degrades cyclic tetra-adenylate, neutralizing type III CRISPR immunity in bacteria and archaea.

This paper introduces parsimony-guided tree moves to improve convergence and mixing in Bayesian phylogenetic inference, showing they outperform standard MCMC methods on empirical datasets.

The paper develops a method to generate diverse peptide libraries in mammalian cells using an ldsDNA-based AND gate genetic circuit, demonstrating sequence and length diversity through HTS and identifying an MDM2-interacting peptide.

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.

This study evaluates how different nitrogen fertilizer rates affect tuber yield and processing quality of two potato cultivars, finding optimal rates for high yield and quality.

The paper shows that Asgard and CPR metagenome assembled genomes (MAGs) fail to meet basic phylogenetic criteria due to their anomalous ribosomal protein evolutionary histories, suggesting they are binning artifacts.

The paper shows that 3D matrix stiffness and dimensionality influence the expansion of hematopoietic stem and progenitor cells in vitro, affecting lineage fractions and gene expression.

The paper investigates the phylogenetic placement of mitochondria within Alphaproteobacteria using alternative methods to address compositional heterogeneity.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

This paper uses molecular dynamics and computational design to analyze the stability of a therapeutic antibody Fab fragment under low pH and high temperature, identifying key regions for stabilization.

This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

This study shows that MET/FAK signaling can activate CDK2 independently of CDK4/6, leading to cell division, and suggests targeting MET/FAK could enhance CDK4/6 inhibitor therapies.

This paper develops a method to identify transgene-free CRISPR-edited rice and tomato plants by monitoring DsRED fluorescence in dry seeds, reducing the need for germination and multiple generations.

The paper introduces a Nanopore-based sequencing method to rapidly map transgenic alleles in the soybean genome, offering a high-throughput and cost-efficient approach.

This study analyzes UHC progress in Ghana from 1995 to 2030, projecting coverage and financial protection, while highlighting inequalities across wealth and regions.

The paper describes new developments in the BEAST 2.5 software platform for Bayesian evolutionary analysis, expanding joint inference over multiple data types and complex phylodynamics.

This study characterizes the rhizosphere fungal community structure of tetraploid cotton and finds it varies with soil type, cotton genotype, and developmental stage.

The paper analyzes the hypothalamic transcriptome of Muscovy ducks across reproductive stages to identify gene expression changes and pathways involved in broodiness.

This study identifies AhRLK1, a peanut receptor-like kinase, which enhances resistance to Ralstonia solanacearum in tobacco through hypersensitive response and hormone signaling.

This study uses Bayesian tip dating to analyze morphological evolution in Mesozoic birds, finding heterogeneous evolutionary rates across body regions.

This study identifies essential genes for Sulfolobus islandicus growth, challenges previous assumptions about essential functions, and highlights genes with unknown roles.

The paper develops focused classification strategies for single-particle cryo-EM to analyze structural variability and allostery, applying them to an HIV-1 TAR element RNA dataset.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

The paper determines the structural basis of CRISPR-Cas13d's RNA-guided ribonuclease activity through cryo-EM and biochemical analysis, revealing its molecular architecture and activation mechanisms.

The paper profiles sgRNA activity in E. coli to improve CRISPR/Cas9 efficiency and identifies limitations of existing prediction models.