C. Zhang

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

This study shows that coronatine, a bacterial toxin, more effectively regulates the Arabidopsis circadian clock than plant-derived jasmonates.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

This study synthesizes and evaluates drimane sesquiterpenoids for antifungal activity, identifying drimenol as a broad-spectrum antifungal agent effective against multiple fungal species and resistant strains.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study shows that dynamic mechanical cues in crowded cell populations enhance collective responses in NF-κB signaling and nuclear shape fluctuations through mechano-signaling feedback loops.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

RosENet improves binding affinity prediction by combining 3D convolutional neural networks with voxelized molecular mechanics energies, achieving an RMSE of 1.26 on the PDBBind v2016 core set.

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study identifies BLOS1 as a mediator of kinesin switch during LDLR endosomal recycling, showing its role in RE transport and LDL clearance.

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

This study identifies a cooperative two-site binding mechanism for C5aR activation using atomic force microscopy, steered molecular dynamics, and functional assays.

This study identifies an optimized mRNA UTR combination (NASAR) that significantly enhances SARS-CoV-2 antigen expression in vitro and in vivo.

The paper maps spatiotemporal proteomic heterogeneity during the cell cycle using single-cell proteogenomics and identifies 235 cell cycle-associated proteins.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

Endosidin20 inhibits plant growth and synergizes with other cellulose synthesis inhibitors, showing potential as a spray herbicide.

This study shows that sphingolipids with very long-chain fatty acids regulate vacuole fusion by affecting membrane fluidity and Ypt7 function in yeast.

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

This study uses genomic data to estimate the origin and transmission dynamics of 2019-nCoV, finding the MRCA date and a decline in the effective reproductive number around January 2020.

The paper constructs a nanobody library in mammalian cells using an ldsDNA-based AND gate genetic circuit, generating 22,173 unique sequences.

This study identifies alkyl-quinolones as surface-induced cytotoxins in Pseudomonas aeruginosa and shows their role in virulence regulation.

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

The paper shows type I interferon responses to ischemic injury start in the bone marrow of mice and humans, involving Tet2, Nrf2, and Irf3, and identifies ISG scores as a clinical biomarker.