F. Zhou

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

This study shows that basic fibroblast growth factor (bFGF) undergoes liquid-liquid phase separation on the cell surface with heparan sulphate proteoglycans (HSPG), which is essential for downstream signaling.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study shows blebs form signaling hubs that promote anoikis resistance in cancer cells by recruiting septins and activating ERK/PI3K pathways.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

This study shows archaeal extracellular vesicles, produced via ESCRT machinery, transfer DNA and support nutrient cycling in extreme environments.

This study uses proteomics to identify complement cascade pathway changes in gastric signet ring cell carcinoma tissues compared to adjacent regions and adenocarcinomas.

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

The paper shows amoeboid melanoma cells migrate through crowded environments by mechanically degrading extracellular matrix via bleb-driven abrading, without proteolysis.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

The paper shows that spatially restricted immune responses in plant roots allow meristematic activity during bacterial colonization by distinguishing cell-autonomous and non-cell autonomous responses.

This study uses computational modeling to show that UBIAD1 mutations in Schnyder corneal dystrophy disrupt GGPP binding to HMGCR, increasing structural flexibility and promoting their interaction.

The paper studies quasi-periodic cell migration on microlanes and shows that a Cellular Potts model can recapitulate migration statistics with minimal cytoskeleton dynamics.

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

This study shows that viral infection can restore MHC-I expression and enhance T cell function, leading to tumor regression in a mouse melanoma model.

This paper describes a rapid, economical method for fabricating multilayer organs-on-chips using laser cutting and assembly, demonstrating its effectiveness for culturing primary human intestinal epithelial cells and organoids.

This study identifies miR-20a/LRIG1/EGFR axis as a regulator of gastric cancer multidrug resistance and suggests it as a therapeutic target.

This study shows eIF4A enhances mRNA recruitment by interacting with the PIC and modulating ribosomal subunit conformation, regardless of mRNA structural complexity.

This study characterizes t-Darpp's structure, metal-binding, and phosphorylation by CDK1 and CDK5, revealing its monomeric form and calcium-binding properties.