G. Wang

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper uses graph theory to model temperature-dependent non-covalent interactions in TRPV1, showing how grid-like networks maintain its structure and govern heat-sensing.

This study uses a grid thermodynamic model to show that PIP2-dependent thermorings in TRPM8 are crucial for cold sensing through structured temperature-dependent interactions.

A third dose of Pfizer/BioNTech vaccine significantly boosts Omicron neutralizing antibodies, while convalescent sera and therapeutic antibodies show variable and often low neutralization.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

This study shows that prostate tumor-induced stromal reprogramming produces Tenascin C, which promotes metastasis by inhibiting YAP/TAZ through 5{beta}1 integrin.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows that PPAR agonists like WY14643 increase herpesvirus replication and inhibit IFNβ production, independent of PPARα expression.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study compares salt tolerance mechanisms in two extremophytes, showing they use distinct pathways to achieve similar adaptive traits.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

This study identifies key traits enabling Schrenkiella parvula to maintain growth and reproductive success under salt stress.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study identifies adaptive features of the desert plant Anastatica hierochuntica by comparing its transcriptome to Arabidopsis thaliana under heat stress, revealing gene selection and expression patterns linked to heat tolerance and desert adaptation.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study analyzes ACE2 gene conservation and expression patterns in 11 animals, finding high conservation but species-specific RNA and protein expression.

This paper introduces a bifocal parallax single particle tracking method to study 3D rotational and translational motion of cargo in living cells, revealing new interactions at microtubule intersections.

This paper uses Maxent modeling to predict the global distribution of talaromycosis, identifying key environmental and epidemiological drivers.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.