G. Wang

Parasitism and locomotory capacity calibrate the mitogenomic evolutionary rates in Bilateria

The paper examines mitogenomic evolutionary rates in Bilateria, finding that parasitism and reduced locomotory capacity are associated with elevated rates, explaining a significant portion of variance in branch lengths.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy

This study determines the solution structure of human Atg3 and shows how its dynamic regions and membrane interactions facilitate LC3-PE conjugation during autophagy.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

Genome-wide Identification and Expression Profile Analysis of Laccase Family Genes in the Hypsizygus marmoreus

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

Curvature Sensing and Membrane Remodeling of the VPS37A N-terminal Domain during Autophagy

This study identifies two hydrophobic motifs in VPS37A that bind curved membranes, essential for autophagosome biogenesis.

Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ Disaggregase CLPB

The paper was withdrawn due to duplicate posting and is no longer available for citation.

Spatiotemporal gene expression atlas of the extremophyte Schrenkiella parvula

This study creates a spatiotemporal transcriptome atlas of Schrenkiella parvula, revealing gene expression networks and responses to salt stress across developmental stages and tissues.

The Network Basis for the Structural Thermostability and the Functional Thermoactivity of Aldolase B

This study uses graph theory to analyze how temperature-dependent noncovalent interactions in aldolase B and its A149P mutant form a grid-like network that regulates structural thermostability and functional thermoactivity.

The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response.

The paper identifies ICL-1 as a protein that protects against mitochondrial superoxide stress by activating the mitochondrial unfolded protein response.

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

Drivers of interlineage variability in mitogenomic evolutionary rates in flatworms (Platyhelminthes) are multifactorial

This study identifies multiple factors influencing mitogenomic evolutionary rates in flatworms, with parasitism having the greatest impact despite its monophyletic origin.

MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

Novel Viroid-like RNAs Naturally Infect a Filamentous Fungus

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

The frequent occurrence and metabolic versatility of Marinifilaceae bacteria involved in organic matter mineralizationas a key member in global deep sea

This paper identifies Marinifilaceae bacteria as key players in deep-sea organic matter mineralization, revealing their metabolic versatility and role in carbon and nitrogen cycling.

Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

Uncovering Lasonolide A biosynthesis using genome-resolved metagenomics

This paper identifies the biosynthetic pathway for lasonolide A in a marine sponge-associated bacterium using genome-resolved metagenomics.

KDM4A promotes the progression of neuroendocrine prostate cancer

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

Spatiotemporal atlas of the fetal brain depicts cortical developmental gradient in Chinese population

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

Pan-cancer quantification of neoantigen-mediated immunoediting in cancer evolution

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

Delta-Omicron recombinant escapes therapeutic antibody neutralization

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-Omics

The paper uses single-cell multi-omic analysis to study TP53-mutant cancer evolution in leukaemia, identifying a role for chronic inflammation in promoting TP53 mutant clones.

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

This paper develops human bone marrow organoids to model hematological malignancies and validate therapeutic targets.