H. Chen

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

SAI automates stomatal parameter quantification on microscope images, achieving results consistent with human experts and improving efficiency in plant physiology research.

This paper identifies a novel daidzein reductase gene C1-07020 from Clostridium C1 that exhibits bidirectional enzyme activity and is widely distributed in human and animal gut microbiomes, offering new insights into (S)-equol production and potential applications.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

This study examines the effects of knocking out LHCB1 in Arabidopsis thaliana, showing reduced chlorophyll levels, altered photosystem absorption, and changes in thylakoid structure.

The paper identifies ORA47 as a transcriptional regulator involved in the general stress response by interacting with the RSRE motif and functioning with CAMTA3 and JAZ1.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

The paper identifies CDRH3 loops in the naive B cell receptor repertoire that can be engaged by candidate immunogens using a combined experimental and computational approach.

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

This study introduces a transparent ultrasound transducer as a cranial window for multimodal imaging of awake mouse brains.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

This paper engineers RNA viruses with an unnatural amino acid to create adjustable immune responses in mice, demonstrating potential for vaccine development.

This paper presents a method using unnatural amino acid-engineered drug-resistant influenza virus to sterilize drug-resistant strains, validated in vitro and in animal models.

This study identifies MSD2, an apoplastic Mn-SOD in Arabidopsis, showing it modulates ROS distribution in roots during skotomorphogenic growth.

The paper shows NDR1 overexpression enhances pathogen resistance at elevated temperatures by maintaining immune signaling during ETI.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This paper introduces a transparent ultrasound transducer array that enables real-time multimodal imaging combining ultrasound, photoacoustic, and optical contrasts.

This study identifies mTOR inhibition as a strategy to overcome RSK3-mediated resistance to BET inhibitors in small cell lung cancer, enhancing apoptosis and antitumor efficacy.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

This study identifies BET bromodomain proteins as coactivators of NEUROD1 in SCLC, showing that BET inhibitors suppress NEUROD1-target genes and reduce tumor growth.

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

This paper shows that the Wolbachia CinB nuclease alone can induce cytoplasmic incompatibility in Drosophila males, with rescue by cognate CifA in females.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.