H. Chen

This study uses an ensemble of explainable AI models to uncover expression signatures of synergistic drug response in AML, revealing a hematopoietic differentiation signature as a key factor.

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

This study shows SARS-CoV-2 exploits sex-specific IFN and TNFα signaling to enhance ACE2 and TMPRSS2 expression in male alveolar cells, promoting viral entry and suggesting potential therapeutic targets.

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

The paper develops Kaptive databases for O- and K-antigen serotyping of Vibrio parahaemolyticus using whole genome sequencing data.

This paper introduces a method combining bioluminescence with phasor analysis to rapidly differentiate multiple luciferase reporters and resonance energy transfer processes in time-lapse imaging.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study shows NDR1 is required for drought tolerance and immunity by regulating H+-ATPase activity and stomatal dynamics in Arabidopsis.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This paper develops a mouse model of PanNETs driven by Cdk5 and shows its relevance to human tumors, supporting Cdk5 as a therapeutic target.

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

The paper develops methylation-based models to predict maximum lifespan and other life history traits in mammals using data from 12,000 samples across 192 species.

This study identifies hepatocytes as the primary source of thrombopoietin (TPO) required for hematopoietic stem cell regeneration after myeloablation.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

This study uses optically pumped magnetometers to investigate muscle fatigue, showing that magnetomyography can detect frequency decreases similar to electromyography and provides spatial signal information.

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.