H. Wang

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

This study identifies glucocorticoid receptor activation in NK cells as a mechanism driving AREG-mediated immunosuppression in skin cancer, with therapeutic implications.

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

This paper modifies GROMACS to support CIF format for molecular dynamics simulations, enabling processing of large protein complexes.

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

The paper develops NYUS.2, an automated machine learning model for real-time simulation of grapevine freezing tolerance in North America, outperforming previous models with lower error.

This study shows that apyrase in Arabidopsis regulates phosphate uptake by metabolizing extracellular nucleotides, affecting root system architecture and auxin signaling under phosphate limitation.

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

This paper develops three Mn(II)-based MR probes to image aldehydes in fibroproliferative diseases, showing improved relaxivity and noninvasive detection of tissue fibrogenesis in mouse models.

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

This study uses phylogenomic analyses with extensive taxon sampling to propose a new infrageneric classification of Pourthiaea, finding cytonuclear discordance and hybridization as key factors.

The paper develops a spatial quantitative systems pharmacology model for virtual clinical trials in HCC, validated with spatial multi-omics data from a neoadjuvant immunotherapy trial.

The paper uses genomic and eco-morphological analysis to reveal recent diversification in the Stellera chamaejasme L. complex, driven by Pleistocene glaciation and biotic factors.

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

This study shows that the diatom Thalassiosira pseudonana can use biogenic phosphonates as a phosphorus source, affecting its elemental stoichiometry and growth under phosphorus starvation.

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

This study shows that TWP leachate ecotoxicity transfers from algae to rotifer through food chains and accumulates across generations, increasing ecological risk.

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

The study identifies a suppressor mutation in HSV-1 NEC that stabilizes the hexagonal lattice, restoring membrane budding in various mutants.

This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.