H. Wang

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.

This study identifies epithelial NMDA receptors in the kidney that mediate vasodilation via connecting-tubule-glomerular feedback by enhancing ENaC activity.

DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic Exposure

This study uses high-throughput evolution to explore antibiotic resistance landscapes in E. coli exposed to low-level antibiotics, identifying key mutations and developing predictive models.

The Myc-Like Mlx Network Impacts Aging and Metabolism

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

Comparison of urinary proteome in the first two days after mating in male rats

The paper compares the urinary proteome of male rats on the day of mating and the next day to identify proteins related to spermatogenesis.

Melatonin serves as a novel treatment in cystic fibrosis and inhibits cystic fibrosis through TGF-β1/Smad and EMT

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

An Artificial Intelligence-Assisted Digital Microfluidic System for Multistate Droplet Control

This paper introduces an AI-assisted digital microfluidic system called DropAI for multistate droplet control using semantic segmentation and state machine feedback.

scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases

scDrugPrio uses single-cell RNA sequencing to prioritize drugs for immune-mediated inflammatory diseases, showing personalized drug response variations across patients.

Protein thiol alterations drive aberrant phase separation in aging

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G.duodenalis parasite

This study presents high-resolution atomic structures of two Giardiavirus strains, revealing structural features associated with extracellular transmission and virulence in Giardia duodenalis.

Identification and functional analysis of eRNA markers for hepatocellular carcinoma based on high-throughput data

This study identifies three eRNA biomarkers for hepatocellular carcinoma (HCC) and shows their involvement in cancer progression, prognosis, and potential as therapeutic targets.

Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1 and is Independent of the Wnt Signaling Pathway

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

This study identifies and evaluates LFS-1107, a CRM1 inhibitor that suppresses ENKTL cell growth by blocking NF-κB signaling and shows promise for clinical translation.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension

This study shows LOXL2 inhibition reduces pulmonary artery stiffness and improves survival in pulmonary hypertension models.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Physiological and transcriptomic characterization of cold acclimation in endodormant grapevine under different temperature regimes

This study investigates how different temperature regimes affect cold acclimation in endodormant grapevine buds using physiological and transcriptomic analyses.

Yes1-mediated Cul9 phosphorylation promotes the metabolic reprogramming in gastric cancer

This study identifies Yes1-mediated Cul9 phosphorylation as a driver of metabolic reprogramming in gastric cancer, revealing a feedback loop with therapeutic implications.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

An inducible ESCRT-III inhibition tool to control HIV-1 budding

This paper develops a drug-inducible tool to inhibit HIV-1 budding by transiently stabilizing ESCRT-III components, showing varying effects on VLP release.

FluxNorm: Toolbox for metabolic flux assay normalization by in situ cell counting

FluxNorm normalizes metabolic flux data by in situ cell counting to accurately assess cellular bioenergetics across experimental conditions.

Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Cell Migration and Cell Cycle Progression

This study shows that vinculin's interaction with Arp2/3 inhibits branched actin assembly, affecting cell migration and cell cycle progression in mammary epithelial cells.

Changes in the urinary proteome of rats after short-term intake of magnesium threonate

This study examines changes in the urinary proteome of rats after short-term magnesium threonate intake, identifying differential proteins linked to magnesium's biological functions.

Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

The paper examines how human disturbance affects spatiotemporal associations among mountain forest terrestrial mammals using camera-trap data from the eastern Himalaya.

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.