H. Wang

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

This study shows that bariatric surgery reduces MASH through TREM2-expressing hepatic macrophages, independent of weight loss.

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

This study identifies dysfunctional T follicular helper cells in NASH as a driver of intestinal and hepatic inflammation using a mouse model.

The paper determines the structures of EHEP and akuBGL to elucidate how EHEP protects akuBGL from phlorotannin inhibition.

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

The paper shows that Escherichia coli uses outer membrane vesicles to remove over-replicated DNA through the XerCD recombinase complex.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study provides evidence that cough contagion in humans is driven by empathy, not physiology, showing no time difference and gender-based susceptibility.

The paper shows RSK2 compensates for MLCK loss in smooth muscle contractility through a novel signaling pathway involving PDK1 and Erk1/2.

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

This study identifies 14-3-3 proteins as regulators of lipolysis in human adipocytes by analyzing the PLIN1 interactome using proximity labeling.

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

This study finds that consuming traditionally fermented foods increases antibiotic resistance in gut microbiota, posing a public health risk.

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

This paper introduces DeepSEED, an AI framework for designing synthetic promoters by optimizing flanking sequences, showing improved performance in prokaryotic and eukaryotic systems.

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

The paper investigates reticulate evolution in the genus Stranvaesia using phylogenomic data, revealing how hybridization and allopolyploidy influence taxonomic classification and leading to the description of a new genus.

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

This study identifies CATSPER{theta} as essential for CatSper channel assembly in sperm flagella, revealing its role in channel formation and flagellar trafficking, leading to male infertility in its absence.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

The paper identifies two membrane-like pre-stem progenitors that develop into c-kit-positive stem cell progenitors and multi-nucleated cells, challenging existing concepts of stem cell self-renewal and lineage origins.