H. Wang

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

The paper shows that calling from the ground significantly increases acoustic efficiency for crickets and other animals, challenging the view of ground as an impediment.

This study identifies FAP106 as a critical interaction hub for assembling conserved and lineage-specific microtubule inner proteins at the cilium inner junction in Trypanosoma brucei.

This paper conducts a bibliometric analysis of immunotherapy research in pancreatic cancer, identifying key trends, hotspots, and future directions.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study shows that exposure to tire wear particle leachate across multiple generations impairs reproduction in rotifers, leading to population collapse.

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

This study evaluates the impact of Fcγ receptor affinity on CAR T cell efficacy and safety, finding that moderate affinity provides optimal antitumor activity while high affinity causes toxicity.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

This study reveals how Vma12p, Vma21p, and Vma22p assemble and regulate V-ATPase VO region to prevent premature V1 binding and ensure proper acidification of cellular compartments.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This study evaluates how bioaugmentation and biostimulation affect microbiomes and nitrate removal in woodchip bioreactors under cold conditions.

This study identifies two progenitors of sweetpotato using horizontal transferred T-DNA and haplotype-based phylogenetic analysis, revealing its origin from a reciprocal cross and whole genome duplication.

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

This study links temperature stability and cool seasonal maxima to higher diversification rates in Pieridae butterflies, using a comprehensive phylogeny and distribution data.

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of 293T cell membranes, showing lipid bilayer thickness and protein distribution.

This study investigates how mast cell-conditioned medium affects melanoma spheroid growth and gene expression, suggesting nutrient starvation may explain observed phenotypic changes.

This study analyzes gene expression and physiological responses of passion fruit buds under high-temperature stress, identifying key genes and pathways involved in stress response.

The paper identifies transgressive and parental dominant gene expression and methylation patterns in Brassica napus hybrids during seed development, linking them to early heterosis mechanisms.

The paper develops a microfluidic model of PIK3CA-driven vascular malformations and identifies dysregulated Rac1/PAK and mTORC1/2 signaling as key factors in lesion formation.

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

This study identifies OPRIII genes in wheat that modulate root architecture and grain yield under water stress through jasmonic acid signaling.

The paper investigates the functional hierarchy of Rab27 effectors in insulin secretion by comparing exocytic phenotypes in beta cells lacking different combinations of effectors.

This study establishes a Tetrasphaera-enriched microbiome for enhanced biological phosphorus removal using allylthiourea, achieving high nutrient removal and recovery.

This study identifies a Golgi-dependent pathway involving Arf1 and Sec71 that regulates microtubule growth and reactivates quiescent neural stem cells in Drosophila.

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

This study uses target sequence capture data to analyze the evolutionary relationships within the subgenus Chamaecerasus of Lonicera, revealing polyphyly and proposing taxonomic revisions.