H. Wang

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study observes and attributes intermittent bioluminescence blinking in native bacteria to stochastic gating of Na+/H+ antiporters, revealing their dynamic behavior in living cells.

This paper introduces an environmentally-friendly aerosol filter made from whey protein nanofibrils and iron oxyhydroxides nanoparticles that efficiently traps various viruses.

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

The paper identifies two substrate-binding sites in pOmpT that enable specific cleavage of human AMP RNase 7, revealing structural basis for substrate specificity and drug development clues.

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

This study demonstrates that Notch ligand dimers mediate cis-inhibition of Notch receptor activity, introducing a new model of Notch signaling that distinguishes between ligand monomer-driven transactivation and dimer-mediated cis-inhibition.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

PvC3H29 interacts with PvNAP1&2 to inhibit their transactivation on chlorophyll catabolism and leaf senescence in switchgrass.

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

The paper designs long-acting GLP-1 receptor agonists using structural biology to prevent DPP-4 degradation while maintaining receptor binding, achieving hypoglycemic effects lasting over 24 hours.

This study shows that Bcl3 in classical dendritic cells is critical for host protection against Toxoplasma gondii by regulating antigen presentation and T cell responses.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

This paper describes a method using calcineurin fusion to improve cryo-EM structure determination of Family A GPCRs by enhancing particle alignment.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.