J. Guo

This study investigates the divergent evolution of zygomycete fungi, identifying lineage-specific genomic elements and evolutionary relationships that contribute to Mucormycosis pathogenicity.

This study shows that persistent macrophages after AKI promote a proinflammatory environment leading to tubule damage and CKD progression.

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

The paper quantifies how meal characteristics like energy density and eating rate affect energy intake across different dietary patterns in adults.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

The paper investigates how mechanical communication between cells leads to directional migration and branching connections, mediated by calcium channels, integrin β1, and N-cadherin.

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

This study shows that Angptl2 in vascular smooth muscle cells promotes abdominal aortic aneurysm development under inflammation.

This study compares bone marrow interstitial fluid and peripheral blood plasma in pediatric acute lymphoblastic leukemia, finding distinct metabolic, lipid, and protein profiles before and after chemotherapy.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

Proteomics identified differences in wheat resistance to Pst and Bgt, with TaGSTU6/TaCBSX3 interaction specifically enhancing resistance to Bgt.

This paper develops a deep learning pipeline to segment macroscopic colony patterns of Proteus mirabilis, achieving high accuracy in identifying colony boundaries and internal ring structures.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This paper introduces a method to genetically incorporate a nonhydrolyzable phosphotyrosine analog into mammalian proteins to study tyrosine phosphorylation without dynamic interconversion complications.

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

This study identifies MAPK-associated phosphorylation sites in RSG that regulate its subcellular localization and function in tobacco.

This study uses experimental evolution to generate E. coli with radiation resistance similar to Deinococcus radiodurans, revealing multiple genomic and proteomic changes involved in IR resistance.

The paper identifies boundary domain genes tsh1 and lg2 that suppress inflorescence leaf growth and promote branching in maize through regulatory networks and gene duplication events.

This study shows that Chikungunya virus replicates more efficiently in mammalian cells at sub-physiological temperatures due to reduced antiviral responses and enhanced stress granule recruitment.

The paper identifies ERN1, a G-lectin receptor kinase, as a negative regulator of Arabidopsis immunity against root-knot nematodes by suppressing defense responses.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

The paper identifies a mutation in Abl kinase that causes imatinib resistance through altered drug dissociation kinetics rather than reduced binding affinity.

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

This study shows TMEM120A does not mediate poking- or stretch-induced currents and identifies a specific coenzyme A-binding site through cryo-EM structures.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.