J. Jin

This study shows that muscle stem cells in their native niche experience mechanical deformation from myofiber stretch-shortening and respond with increased nitric oxide production and gene expression related to proliferation.

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

This study shows that low-dose adenovirus vaccines administered via microneedle patches to the skin induce better functional antibody responses than systemic injection.

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

The paper presents a near-atomic resolution cryo-EM structure of Mayaro virus, revealing structural determinants of alphavirus particle formation and identifying key residues involved in assembly.

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

The paper analyzes SARS-CoV-2 genomic mutations and phylogeny in Gwangju, South Korea, showing clustering in clade V and G and highlighting the importance of genomic surveillance for vaccine and therapy development.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

Thiol drugs inhibit SARS-CoV-2 infection in vitro and reduce lung injury in vivo, supporting their potential as COVID-19 treatments.

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

The paper uses molecular dynamics simulations to show IP6 stabilizes HIV-1 capsid pentamers over hexamers, enhancing capsid stability.

The paper identifies lineage-specific human placental enhancers associated with endogenous retroviruses, revealing their role in placental evolution.

The paper designs ACE2-Fc variants with lost enzymatic activity but retained antiviral function to avoid cardiovascular side effects.

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

This study evaluates phase-dependent gait stability measures in compass walker models to predict gait robustness and identifies limitations in their predictive accuracy across different state space representations.

The paper investigates tissue-engineered urethra using collagen/chitosan scaffolds and reports a new method for quantifying epithelial cell activity.

The paper establishes a zebrafish model of G6PD deficiency that replicates key clinical features observed in humans with the condition.

This paper establishes a stable transgenic zebrafish model of G6PD deficiency that mimics clinical features and shows reduced GSH levels and G6PD abundance.

The paper designs a soluble ANGPT1 mimetic, C4BP-ANG1, which activates Tie2 and reduces vascular leakage in models of inflammation.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

This study shows that inhibiting SETD8 reduces multiple myeloma cell survival and overcomes drug resistance regardless of p53 status.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

The paper uses p19 to capture RNase III-cleaved dsRNA in E. coli, revealing widespread antisense transcription and its potential role in stress responses.

This paper identifies a stable expression hot spot in Chinese hamster ovary cells using a lentivirus-based random integration method and validates its long-term expression stability.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

This study shows pirfenidone reduces fibrotic responses in lung fibroblasts by inhibiting CTHRC1, suggesting it as a potential therapeutic target for lung fibrosis.