J. Kim

This study identifies a loss-of-function mutation in Itgal as a contributor to extreme susceptibility to Salmonella infection in the Collaborative Cross strain CC042.

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

This study uses finite element modeling to show that MitraClip increases leaflet stress and myocardial strain in patients with functional mitral regurgitation and coronary disease, with effects amplified by left ventricular enlargement.

DeepTetrad uses deep learning to analyze pollen tetrads and measure crossover frequency and interference in Arabidopsis plants.

The paper identifies proteasome-dependent degradation of PAL as a mechanism linking glucosinolate and phenylpropanoid biosynthesis through regulation of KFB genes.

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

This study shows that gene positioning near nuclear speckles enhances transcription levels through a mechanism distinct from transcriptional bursting.

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

This study investigates how cells respond to 3D topographical cues in engineered matrices, finding that myosin II regulates protrusion orientation in response to aligned fibers.

This paper optimizes DNA extraction from human urine to better profile both bacterial and fungal communities using next-generation sequencing.

The paper develops a computational solution to improve biomarker reproducibility across ELISA kit lots in long-term projects by modeling standard curve shifts and adjusting data accordingly.

The paper reports crystal and SAXS structures of EspG chaperones from mycobacterial ESX systems, revealing structural variability and potential substrate binding modes.

This paper isolates an antibody from a recovered SFTS patient that inhibits multiple SFTSV strains and protects mice from infection, suggesting its potential as a therapeutic agent.

This study shows that sialyllactose enhances bacterial clearance in mice and human macrophages through receptor-mediated endocytosis, phagocytosis, and Rac1-mediated reactive oxygen species production.

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

The paper uses transfer entropy to analyze information flow between QT and RR intervals, finding asymmetry and history effects, and shows current QT correction methods fail to capture these dynamics.

The paper introduces a new soil extract medium (ISEM) that isolates previously uncultured bacteria, with 49% of isolates being previously uncultured and 55% representing new taxonomic candidates.

The paper uses genomic profiling of tumor spheroids from malignant ascites to evaluate tumor evolution in an ovarian cancer patient, finding genetic differences between primary tumor and spheroids.

This study shows that Ezh2 ablation in neural crest cells causes Hirschsprung's disease-like symptoms in mice by disrupting gene regulation.

This study shows that different hippocampal projections to the anterior olfactory nucleus convey spatial and temporal information for episodic-like odour memory.

The paper introduces SHACKTeR, a method for live cell imaging of specific chromosomal regions using CRISPR/Cas9 and TetO repeats, successfully labeling 9 loci in HCT116 cells with up to 20% efficiency.

The paper identifies de-differentiated, inflammatory cancer-associated adipocytes in breast cancer and shows that miR-5112 promotes IL6 expression through targeting Cpeb1.