J. Kim

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

This study shows that DNMT3A in skeletal muscle regulates oxidative capacity and endurance exercise by controlling ROS production through ALDH1L1.

The paper studies client recruitment in biomolecular condensates using poly-SUMO and poly-SIM proteins, finding that filament structure influences functional client binding.

This study identifies that Zika virus infects pericytes in the choroid plexus and crosses the blood-CSF barrier to enter the CNS, with CSF neutralization reducing brain infection.

This study shows that combining sunitinib with cRGDfK enhances inhibition of TGF-β1-induced EMT in lung cancer cells by targeting Wnt and Smad pathways.

This study identifies CCM1 as a regulator of YAP/TAZ signaling that promotes prostate cancer metastasis and is inversely correlated with patient survival.

This paper develops a deep learning pipeline to evaluate nuclear segmentation models trained on small, custom annotated datasets, showing they can match or exceed performance of pre-trained models.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

This paper develops a LAMP assay for rapid and accurate identification of Spodoptera frugiperda using a specific mtDNA region, showing high sensitivity and simplicity.

The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.

This study shows that non-lethal H2O2 exposure primes bacterial survival and accelerates evolution of resistance to oxidative stress.

This study investigates the role of septin 2 in endothelial cell junction organization, showing its localization is critical for maintaining junctional integrity and that TNF-α disrupts this localization.

This paper introduces an acoustofluidic device to create 3D neurospheroids for modeling Alzheimer's disease neuroinflammation and amyloid-β toxicity.

This study evaluates Telacebec's efficacy in shortening Buruli ulcer treatment in mice, showing it can cure infections in as little as 1 week with no relapse.

The paper introduces a metric space for ranked genealogies to analyze evolutionary processes across multiple time periods and applies it to infectious disease studies.

This study uses OCTA to detect microvascular changes after EPB, finding reduced capillary density and increased nonperfusion even without visible retinopathy.

The paper shows ACKR2 and CCR1 regulate macrophage dynamics and mammary gland development by controlling CCL7 levels and macrophage movement.

This study shows that BMI1 and RNF2 suppress transcription-replication conflicts and CFS instability by regulating RNA Pol II elongation and fork protection.

This study investigates the magnetic alignment of SMA-QA polymer nanodiscs using solid-state NMR, showing their orientation changes in response to magnetic fields and paramagnetic salts.

This paper introduces an MRI-based finite element modeling method to predict myocardial ischemia effects in patients with functional mitral regurgitation, showing successful convergence and agreement with experimental data.

This study shows that β-adrenergic receptor signaling regulates cardiomyocyte cytokinesis, and β-blockers like propranolol can enhance division in ToF/PS cardiomyocytes, potentially improving heart function in CHD patients.

This paper develops a CRISPR-Cas12a-based system for rapid, sensitive, and specific ASFV detection without nucleic acid amplification, achieving a detection limit of 100 fM.

The paper develops a model showing how genetic admixture and phenotypes decouple over time, especially with assortative mating and few genetic loci influencing the trait.

This study shows that IHH activates the stromal Hedgehog pathway to suppress lung adenocarcinoma growth and metastasis by reducing reactive oxygen species.

This paper introduces obSTORM, a method for super-resolution imaging of thick samples, achieving isotropic resolution over significant depths.

This study uses mathematical models to show that differential-targeting gene drives can limit spillover to non-target populations, but only under specific parameter configurations and low migration rates.

The paper identifies a novel qepA8 variant in Shigella flexneri associated with reduced ciprofloxacin susceptibility.