J. Li

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.

This study uses CRISPR/Cas9 and assODN to create an isogenic cell model of the HBB -28 (A>G) mutation and analyzes its transcriptome effects, revealing altered gene expression and pathway activation.

The paper reports the crystal structure of SARS-CoV-2 main protease bound to shikonin, revealing conformational changes and binding modes that could inform drug design.

The paper shows that a partial pathogenicity chromosome in Fusarium oxysporum f.sp. lycopersici is sufficient for virulence and can be horizontally transferred, with some partial versions being more virulent than complete ones.

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This paper develops a novel water-soluble photosensitizer, sorbicillinoids, for antimicrobial photodynamic therapy that effectively inactivates Gram-positive bacteria under UV light without significant toxicity.

The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study identifies that senile plaques in Alzheimer's disease originate from Aβ and Cathepsin D-enriched amyloid mixtures formed through intravascular hemolysis and vascular degeneration.

This study shows JAG1-NOTCH4 signaling promotes atherosclerosis by repressing endothelial repair in response to low oscillatory shear stress.

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

This paper develops an inducible mouse model of childhood HIV-associated nephropathy (HIVAN) and shows HIV-Tat contributes to the disease when combined with other HIV-1 genes and heparin-binding cytokines.

This study shows that Asgard archaea possess ESCRT complexes with eukaryotic-like structural and functional features, suggesting they are evolutionary precursors to eukaryotic ESCRTs.

This study shows that Nelfinavir inhibits DDI2, blocking NFE2L1 proteolysis and enhancing the effectiveness of proteasome inhibitors in cancer treatment.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.

This paper identifies the WTp53-HSF1 axis as the driver of p53LOH in colorectal tumors, enabling mutp53 stabilization and invasion.

This study investigates how H-NS proteins evolved to sense environmental changes by comparing orthologs from different bacteria and using biophysical methods to reveal electrostatic interactions involved in adaptation.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

This study shows that lung-stage schistosome infection reduces allergic airway inflammation by increasing allergen-specific Treg cells that inhibit IgE and Th2 cytokine production.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.