J. Li

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

This study shows that PML is required for ALT by localizing the BTR complex to telomeres, and that BTR localization alone can sustain ALT activity.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This study shows that iso-PhABA improves grape color and anthocyanin content more than ABA by enhancing enzyme activity and receptor affinity.

The study examines dominance hierarchies among female Yunnan snub-nosed monkeys using aggressive-submissive behaviors and grooming reciprocity, finding loose hierarchies and higher grooming income for dominant individuals.

The paper uses a mathematical model to show that plant traits like flower density and male-to-female ratio influence kiwifruit yield more than pollinator density or behavior.

The paper identifies genetic signatures in tumor microenvironments to explain resistance to immunotherapy and suggests potential therapeutic strategies.

The paper identifies molecular signatures of inflamed and non-inflamed tumor microenvironments across cancers and suggests potential drugs to convert non-inflamed tumors to inflamed ones.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study identifies a conserved exZZU extension in ankyrins that enhances binding to beta-spectrins through structural interactions, but shows that direct binding does not determine pairing specificity.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

This study shows miR-214 reduces pulmonary angiogenesis and alveolarization in BPD by inhibiting PlGF and STAT3 signaling in hyperoxic rat models.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This paper develops an automated system to measure bower construction behaviors in Lake Malawi cichlids using depth sensing and action recognition, revealing non-uniform and repeatable behaviors across species and hybrids.

This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study identifies KDM6B-dependent chromatin remodelling as critical for virus-specific CD8+ T cell differentiation and memory formation.

This study demonstrates that cross-feeding between Thauera aminoaromatica and Rhodococcus pyridinivorans drives quinoline degradation in a denitrifying bioreactor through 2-hydroxyquinoline as an intermediate.

This paper demonstrates a plasmonic platform using NIR light to generate microbubbles for directed assembly and concentration of micro/nanoparticles, cells, and vesicles.

The paper develops a computational method to detect isoform usage in T cells from non-small cell lung cancer and identifies gene-specific isotype preferences linked to T cell function.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.