J. Li

This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.

SLEAP is a deep learning framework for multi-animal pose tracking that enables accurate and efficient tracking of social interactions across various species and experimental conditions.

This paper introduces 3D-iLLS, a live-cell imaging technique that improves 4D resolution and signal-to-noise ratio by combining SPIM with 4Pi interferometry.

The paper identifies UGT enzymes involved in the biosynthesis of HGL-DTGs in Nicotiana attenuata and shows that glucosylation prevents autotoxicity while enhancing defense against herbivores.

The paper identifies lanthipeptide synthetases as key enzymes in the biosynthesis of 2-aminovinyl-cysteine motifs in thioamitides, revealing their role in dehydration and macrocyclization.

This study shows that e-cigarette vapor causes mitochondrial DNA damage, which activates TLR9 and promotes atherosclerosis in mice.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study shows that Cops8/CSN deficiency in cardiomyocytes leads to necroptosis via the RIPK1-RIPK3 pathway, with Nrf2 and redox stress playing key roles.

This study identifies the Mocln1-calcineurin-TFEB-p62 pathway as mediating cardiac macroautophagy activation due to proteasomal malfunction.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.

This study identifies cell-type-specific regulatory changes in human, chimpanzee, and rhesus macaque cortical neurons, revealing human-specific regulatory elements linked to language and psychiatric disorders.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study identifies gene expression changes and pathways involved in passion fruit ripening and senescence using RNA sequencing and validates findings with RT-qPCR.

This paper proposes a Monte Carlo method to select climate variables for MaxEnt models, demonstrating its effectiveness in identifying key predictors from large climate datasets.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study investigates the pharmacokinetics and pharmacodynamics of inhaled phage PEV31 in mice, showing reduced MDR Pseudomonas aeruginosa burden.

This study shows cadmium impairs iron sensing in Arabidopsis leaves, inducing iron-deficiency responses even with sufficient iron, suggesting a mechanism beyond root uptake competition.

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.

This study identifies genetic factors underlying pigmentation differences between Drosophila species in multiple body parts using QTL mapping and introgression experiments.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.