J. Li

This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

This study identifies dynamic surface and secreted proteins of Aspergillus fumigatus conidia under different conditions and compares them to other allergenic molds.

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

This study introduces a new scallop strain, Bohai Red, and evaluates its hybridization with A. irradians concentricus, finding hybrids show improved survival, growth, and heat tolerance.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

This study shows cancer reduces insulin-stimulated glucose uptake in muscle and adipose tissue and impairs muscle microvascular perfusion in mice.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This paper identifies a sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum that allows growth on sulfoquinovose, producing sulfolactate and contributing to bacterial persistence in soil.

The paper introduces STADIA, a tool to quantify microtubule dynamics, including stutters, and shows stutters precede catastrophes, with CLASP2{gamma} promoting their return to growth.

This study identifies Plasmodium α-tubulin-1 as a binding partner of Anopheles FREP1, showing that anti-α-tubulin antibodies inhibit malaria transmission to mosquitoes.

This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.

The paper determines the crystal structures of three homoserine transacetylases and identifies MtMetX as highly druggable.

The paper develops a method to quantify acyl-ACPs at picogram levels and identifies new intermediates and acyl-ACPs, highlighting gaps in lipid metabolism understanding.

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

The paper develops a cell-based assay to study agonist-selective recruitment of engineered protein probes and GRK2 by opioid receptors in living cells, showing differential recruitment by distinct opioid ligands.

This paper introduces a hydrogel beads platform for single-cell phenotyping and digital molecular detection, demonstrating its utility in analyzing genotype-phenotype correlations.

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This paper identifies a plant-derived tRF, tRF-T11, that suppresses human ovarian cancer progression in vitro and in vivo, showing potent cytotoxicity comparable to taxol.

The paper evaluates molecular heterogeneity in prostate cancer biopsy samples using dual immunohistochemistry and RNA in situ hybridization, finding clonal differences and higher heterogeneity in African American patients.

This study determines the structure of the zebrafish Gpr126 ECR, revealing a closed conformation stabilized by alternative splicing and a calcium-binding site, and shows how these features regulate receptor function.

This study develops a serum-free method to generate human mesenchymal stem cell spheroids using knockout serum replacement, showing similar transcriptomes to FBS-based spheroids and retained MSC markers.

This study evaluates how adding Chinese herbal medicine residues affects antibiotic resistance genes and bacterial communities in chicken manure composting, finding increased ARG removal with higher residue addition.